Sunday, October 28, 2012

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October 27, 2012 18:40 AVG Internet Security - Weak, Ambigous Documentation #219361
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Just installed AVG Internet Security 2013 in workstations in a small-business environment, and using it for the first time. I'm dissatisfied by the lack of good, technical support information in the help section and the amount of abstract concepts such as "Identity Protection", or, misleadingly described and ambigous "Use DNS update" option.

The documentation (Help file) should include more advanced description of the program functionality, specifying the levels and areas of protection in more detailed, technical fashion - what filesystem, system resources & components are monitored, what monitoring mechanisms are used, etc.

Source: http://forums.avg.com/us-en/avg-forums?sec=thread&act=show&id=219361

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Photos: See the best of NatGeo's reader pics

While photographing lilies in a local swamp a cloud of tadpoles swam by numbering in the thousands, all following along in a trail. (Photo and caption Courtesy Eiko Jones / National Geographic Your Shot)

Click here for more photos from National Geographic Your Shot.

While photographing lilies in a local swamp a cloud of tadpoles swam by numbering in the thousands, all following along in a trail. (Photo and caption Courtesy Eiko Jones / National Geographic Your Shot)

Click here for more photos from National Geographic Your Shot.

Source: http://news.yahoo.com/photos/national-geographic-reader-pics-1335464806-slideshow/

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Diet, Diabetes, And Doubt: Is Preventive Medicine Lost In Space ...

From US News & World Report?..

A large federal trial, looking at lifestyle?diet and exercise?for the treatment of diabetes was just terminated because, after 11 years, it wasn?t working as intended. The Look AHEAD study was stopped early because it was not reducing the rate of heart attack and stroke in the intervention group relative to the control. The termination was reported in a press release by the National Institutes of Health, and picked up by mainstream media. The findings suggest that diet and exercise are not effective for reducing the cardiovascular complications of diabetes.

And so, AHEAD, or at least the media coverage of it, is inviting us to look back, and doubt what we thought we knew about diet as the best medicine we?ve got?for diabetes, at least. We thought we knew that lifestyle was among the most powerful determinants of health outcomes. We thought we knew that diet and exercise together could prevent heart attacks in high-risk people. Participants in the AHEAD intervention lost 8 percent of their body weight by the end of the first year of the trial and were still down 5 percent from their baseline weight at the four-year mark. We thought we knew that diet, exercise, and weight management like this exerted important influences on the course of diabetes. Now, the AHEAD findings suggest we were wrong. Right? Not so fast.

For one thing, the trial did generate many noteworthy benefits. Prior papers in the Archives of Internal Medicine and the New England Journal of Medicine have reported significant benefits of lifestyle intervention related to weight loss, fitness, blood glucose levels, blood pressure, cholesterol levels, and mobility. The study was terminated for failing to prevent heart attacks and strokes, but it did reduce medication use, and conferred other benefits?such as a significant reduction in sleep apnea.

To read the full story?..Click here

Source: http://www.lensaunders.com/wp/?p=6025

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Calabasas HS Football: Charity Golf Tournament: Silent Auction ...

Saturday, October 27, 2012

Obama, Romney campaign with eye on storm forecast

Republican vice presidential candidate Paul Ryan raises his arms as he walks to the podium after being introduced at a campaign event at North Canton Hoover High School Friday, Oct. 26, 2012, in North Canton, Ohio. (AP Photo/Tony Dejak)

Republican vice presidential candidate Paul Ryan raises his arms as he walks to the podium after being introduced at a campaign event at North Canton Hoover High School Friday, Oct. 26, 2012, in North Canton, Ohio. (AP Photo/Tony Dejak)

A young girl listens as First Lady Michelle Obama speaks at a campaign rally, Friday, Oct. 26, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

Republican presidential candidate and former Massachusetts Gov. Mitt Romney boards his campaign plane in Akron-Canton Regional Airport, North Canton, Ohio, Saturday, Oct. 27, 2012, as he travels to Pensacola, Fla., for campaign events. (AP Photo/Charles Dharapak)

(AP) ? With an eye on the weather forecast, President Barack Obama and Republican Mitt Romney are starting a 10-day sprint to the finish line in a contest increasingly about momentum versus math.

"Let's win this," Romney emailed supporters Saturday as he hopped a plane from one important state to another ? Ohio to Florida."

"We're defying odds and holding strong," he told his backers, and urged them to contribute more money to help Republicans keep up the fight.

His running mate, Paul Ryan, was out early in rainy, chilly Ohio to visit a factory in New Philadelphia, where he told voters, "You know it's you. You know what you have in front of you. You know your responsibility."

A huge storm barreling toward the East Coast and some battleground states had both campaigns adjusting travel schedules and canceling events. Even at this late date in the campaign, neither side wanted to risk the appearance of putting politics ahead of public safety.

The president was pressing on with a campaign trip Saturday to New Hampshire.

But an email announcing that Vice President Joe Biden's Saturday rally in coastal Virginia Beach, Va., stated that the change was "being taken out of an abundance of caution to ensure that all local law enforcement and emergency management resources can stay focused on ensuring the safety of people who might be impacted by the storm."

Romney canceled a rally in Virginia Beach that was planned for Sunday, and aides said they were also considering scrapping two other events elsewhere in the state. None of Obama's campaign stops had been canceled, but he did adjust his travel schedule slightly. The campaign moved up his planned Monday departure for Florida to Sunday night to beat the storm.

With the Nov. 6 election fast approaching, Obama and Romney are tied nationally. But the president still appears to have more pathways to reaching the required 270 electoral votes.

The Obama campaign released a new TV ad Saturday urging Americans when they go into the voting booth to consider Romney's plans to roll back Wall Street reforms, transform Medicare into a voucher-like system and reduce spending on education while at the same time cutting taxes for the rich. The spot will air in Florida, Iowa, Ohio and Virginia, all key battleground states.

The Republican nominee is trying to seize the momentum mantle and turn a wave of GOP enthusiasm into an electoral victory.

Obama's campaign pressed forward with a get-out-the-vote effort that aides said had them leading or tied in every competitive state. The president was eschewing the lofty rhetoric of his 2008 run in favor of warning supporters that skipping out on voting could cost him the election.

"In 2000, Gore vs. Bush, 537 votes changed the direction of history in a profound way and the same thing could happen," Obama said in an interview Friday with MTV.

Romney was switching his attention to Florida on Saturday after spending much of the week focused on shoring up support in Ohio. While the Midwestern swing state could be crucial to Romney's re-election prospects, he also faces tremendous pressure to carry Florida, which offers 29 Electoral College votes, the most of any swing state.

Obama carried Florida by just 3 percentage points in 2008 and polls show the candidates tied.

The former Massachusetts governor was scheduled to attend three rallies, the first in Pensacola along the state's conservative Panhandle. He then moves to suburban Orlando before finishing his day with an evening rally just outside of Tampa, the site of the Republican National Convention. Romney was to be joined at all three events by Florida Sen. Marco Rubio.

Ryan had his family in tow for the factory visit in New Philadelphia, and his 7-, 9- and 10-year-olds scampered between parts bins and heavy chains.

Ten-year-old Charlie waved the peace sign and mugged for cameras, prompting his mother, Janna Ryan, to shake her head and declare, "I don't know where he gets it. It's kind of crazy."

___

Associated Press writers Philip Elliott in New Philadelphia, Ohio, Steve Peoples in North Canton, Ohio, contributed to this report.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-10-27-Presidential%20Campaign/id-69424e6f08d04648922b2fae2cdb8df4

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Azealia Banks Confirms Lady Gaga, Kanye West Collabos

Banks also reveals the titles of two new Gaga songs — 'Red Flame' and 'Ratchet' — in a Brazilian interview.
By James Montgomery


Azealia Banks
Photo: MTV News

Source: http://www.mtv.com/news/articles/1696281/azealia-banks-lady-gaga-kanye-west-collabo.jhtml

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Tina Fey calls out ?gray-faced men? talking about rape

The comedian Tina Fey has a serious bone to pick with "grey-faced" men who would have their say on women's reproductive rights. Her comments, surfaced by BuzzFeed, have caught interest on the Web.

In a talk at the Center for Reproductive Rights Inaugural Gala last night, the "30 Rock" creator slammed Rep. Todd Akin's definition of "legitimate rape."

The 42-year-old performer, a special guest at the gala, lamented, "I wish we could have an honest and respectful dialogue about these complicated issues. But it seems we can't right now."

The former "Saturday Night Live" star added, "If I have to hear another grey-faced man with a two-dollar hair cut tell me what rape is, I'm gonna lose my mind." In an attempt to sum up Akin's "legitimiate rape" phrase, Fey gave up, saying simply, "I can't even finish this sentence without getting dumber."

In a TV interview this summer, Akin explained why he does not believe abortion should be legal in cases of rape. The congressman claimed, "If it's a legitimate rape, the female body has ways to try to shut that whole thing down."

Just this week, Indiana Sen. Richard Mourdock also came under for fire for saying that "Even when life begins in that horrible situation of rape, that it is something that God intended to happen."

President Obama responded to both of the bizarre explanations of rape during his appearance on "The Tonight Show with Jay Leno," saying "I don't know how these guys come up with these ideas," adding, "Let me make a very simple proposition. Rape is rape. It is a crime."

Source: http://news.yahoo.com/blogs/lookout/tina-fey-calls-grey-faced-men-talking-rape-222011232.html

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Ducking the retirement option | Bankrate.com

My husband will turn 67 in a few months, and he's still working four -- sometimes five -- days a week. For him that's a huge cutback, but not very many people would call that retirement.

About a month ago, he announced at breakfast that he was meeting with his boss and intended to tell him that he planned to retire totally next April. In one way, I was delighted with this retirement planning news because it would give us more freedom to spend winters where it is warmer than it is in Detroit (almost anyplace).

Otherwise, the more I thought about having him spending his days at home with no job, the more concerned I got. What was he going to do all day? And would I have time to keep working, which I enjoy? Fidelity Investments did a survey last year and found that 62 percent of spouses don't agree on retirement timing -- so I'm not alone.

When I was too young to worry about this kind of thing, I was friendly with the wife of a co-worker who was in his 80s and still on the job daily. His wife told me that if he ever retired, she was going to have to pack up and move in with her sister in Indiana. I thought that was a reflection on the stability of their very long marriage. But now I know it was just the normal reaction of a wife who goes a little crazy when she considers the possibility that her husband will be underfoot with nothing to do all day long.

So far, I've dodged this bullet. My husband came home from his conversation with his boss with the news that he's going to keep working -- at least until his boss retires, which isn't imminent. Thank goodness.

Once in awhile, I kvetch about my husband working when I would like to be playing, but after this close call, I'm keeping my mouth shut.

Source: http://www.bankrate.com/financing/retirement/ducking-the-retirement-option/

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Ferrari move to calm navy flag row

GREATER NOIDA, India (Reuters) - Ferrari moved to placate angry Indian authorities on Saturday with an assurance that a navy flag on their Formula One cars was not a political statement of support for Italian sailors detained for killing local fishermen.

The Italian navy flag will, however, remain on the cars for the remainder of the Indian Grand Prix weekend.

Indian motorsports federation (FMSCI) head Vicky Chandhok said he had had talks with Ferrari after the Indian Sports Ministry wrote to him and race promoters expressing concern about the Italian team's gesture.

"(Ferrari) were very clear that they do not want to interfere in the Indian judicial system. They have the utmost respect for India and the Indian public and do not want to hurt any sentiments here," he told Reuters.

"They have given us a fresh statement that is very clear that it (the gesture) is not political in nature."

The two sailors were detained in February on charges of killing two Indian fishermen while protecting a cargo ship off the Indian ocean coast.

Italy says the sailors, who were released on bail in June in the southern state of Kerala, mistook the men for pirates.

Ferrari issued a statement on Saturday saying they had put the flag on their cars as a tribute to "one of our country's outstanding institutions".

The declaration overwrote one published on their website (www.ferrari.com) earlier in the week that had also hoped the sailors' situation would be resolved.

The Sports Ministry, in their letter to grand prix organisers, had asked the FMSCI "to take steps to ensure that the event is not politicised in any manner and sentiments of the people of India are not hurt".

"The ministry have the view that any such action by Ferrari may also be construed as an attempt to subvert the process of justice," the letter added.

Formula One's governing body, the International Automobile Federation, has an apolitical and non-religious stance.

The FMSCI said in a statement of its own that it would "not permit any attempt to subvert the process of justice by politicising" the grand prix.

(Reporting by Alan Baldwin, editing by John Mehaffey)

Source: http://news.yahoo.com/ferrari-move-calm-navy-flag-row-111711857--f1.html

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CACI Awarded $20 M to Continue RBS Support for Naval Supply ...


  • Sustains History of Helping U.S. Navy Stay Supplied and Ready

CACI International Inc (NYSE:CACI) announced today that it has been awarded a prime contract to continue providing Readiness Based Sparing (RBS) solutions for the Naval Supply Systems Command (NAVSUP). With an anticipated ceiling value of $20 million, this three-year (one base plus two options) indefinite delivery/indefinite quantity contract expands CACI's business in logistics and material readiness solutions.

The NAVSUP mission is to deliver sustained global logistics capabilities to the Navy and joint forces. Using RBS solutions, the Navy keeps key equipment and systems mission ready through enhanced inventory management.

The CACI team has been a leader in developing and implementing innovative RBS tools and techniques for more than 25 years. CACI helped the Navy move from traditional demand-based inventory solutions to a comprehensive decision support system that leverages cost, reliability, maintainability, and response time for continuously improving inventory management. CACI's RBS solutions are powerful enough to be used to evaluate the results of conventional logistics information systems, and flexible enough to interface with legacy supply/logistics systems. The result has enabled the Navy to reduce costs while achieving specific goals for maintaining critical supplies and equipment.

John Mengucci, CACI Chief Operating Officer and President of U.S. Operations, said, "This latest Readiness Based Sparing award continues a partnership with the Naval Supply Systems Command that will take us to 30 years of continuous RBS support upon contract completion. We believe this is great confirmation that our operational excellence and solid customer relationships make us a provider of choice."

According to CACI President and Chief Executive Officer Dan Allen, "CACI has pioneered solutions that constantly evolve to help keep our Armed Forces informed, equipped, and mission ready. Our focus on these enduring requirements, coupled with our agility in responding to emerging customer needs, enables us to sustain CACI's growth in a large addressable market and offer innovative solutions and trusted services for our nation's most important missions."

Source : CACI International Inc.

Published on ASDNews: Oct 25, 2012
?

Source: http://www.asdnews.com/news-45777/CACI_Awarded_$20_M_to_Continue_RBS_Support_for_Naval_Supply_Systems_Command.htm

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Block Development Company, TEVA Neuroscience celebrate ...

Kenneth Block, president of Block Development Company, and Larry Downey, chief executive officer of TEVA Neuroscience, celebrate the topping-out ceremony of the TEVA Neuroscience building in Overland Park, Kansas.

The Teva Neuroscience building is an important one in Kansas. The new office building for pharmaceutical company Teva North America will cover 150,000 square feet and house about 350 employees. It will also rise five stories in the air from its site in Overland Park, Kansas.

Most importantly, though, the building is yet more proof that new construction is again on the rise throughout the Midwest.

Construction crews celebrated the ceremonial topping out of the structural steel for the building on Oct. 24.

Kansas City-based Block Development Company played a key role in this project and in bringing the pharmaceutical firm to Overland Park. In an earlier interview with Midwest Real Estate News, Kenneth Block, president of Block Development Company, pointed to the project as a sign of hope in what is still a challenging commercial real estate market.

?It?s good to see construction taking place again,? Block said. ?We?d like to see more construction, of course. We?d always like to see that. But this is one of those projects that we?re all excited about. We think it?s another sign that we are in recovery, even if it is a slow recovery.?

? Dan Rafter

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Source: http://rejblog.com/2012/10/26/block-development-company-teva-neuroscience-celebrate-topping-out-of-new-kansas-office-tower/

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Get An iPhone 5 That Looks Like Unicorn Poop For Only $1700

colorware-iphone-5-xlApple only offers its iPhone 5 in sober black or white/gray, and while I respect their minimalist design sensibilities, some people might want more color options for their smartphone companion. Well, if you're willing to pay more than double the asking price of the unlocked 16GB iPhone 5, you can get whatever color iPhone you want, along with the ability to mix and match for freakish results.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/bnJM_PXZb7U/

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Michigan = Italy = Ohio = France | Michael Ruhlman

Grappa and pear eau de vie made in northern Michigan. Photo by Donna Turner Ruhlman.

I?ve recently returned from inspiring days at Pigstock, in Traverse City, Michigan, where I and my partner in Salumi, Brian Polcyn, were invited to participate in a celebration of the pig. But we also got to sample wines and spirits made from the abundant fruit that grows in this unique climate.

I have, since I first imbibed the crystal elixir, bowed before eau de vie, the aptly named water of life. My first vision of it was in the 1970s when my Uncle Lars arrived at our house with a gift of Poire Williams?for my father;?astonishingly, there was a pear inside the bottle. I did not get to drink from this as I was 10, and my dad felt that if they could get a pear inside a bottle, it deserved to remain sealed and marveled at for at least a year, and then doled out carefully. I was 16 before I got a sip of the magical fluid. (Now, at 49, I am less careful with the portions; Brian and I made considerable headway into the brandy in Traverse City, with only a little help from dear Kate of Camont, who?d made a special stop on her way to Grrls Meat Camp in Chicago. Kate?s first comment: ?It?s so smooth.? Indeed, with a heady pear aroma.)

Ten years later, Donna and I, boyfriend and girlfriend, ?acquainted? for only eight months but in love forever, traveled to Italy to do our first story together on the marble of Carrara. Here I first tasted lardo (1988, when raw pig fat was considered instant death in America; I write about this in the new book), but also grappa, the spirit made from grape skins?byproducts from the wine-making?further fermented into an inferior wine, but then distilled into a wonderful clear spirit. Raw pig fat! Grappa! What a world, I thought.

Unable to buy the stuff in Ohio for years given our Civil War?era liquor laws and unhappy with the industrial lighter fluids available in Florida where my mom lived, I was at last in heaven again this summer on my 49th?birthday (having taken Donna to Italy to celebrate her 5-0 the day before). We splurged on Splendido (go for the rooms by the harbor, Splendido de Mare, not the posh hillside main resort). I bobbed up and down like a cork in the brine-strength swimming pool; we had a lovely lunch and, after, the best grappa they had.

And then, this past Monday afternoon, having cleaned off after the hog slaughter in upstate Michigan, where I?d eaten raw pig fat, warm back fat from the freshly slaughtered Mangalitsa, we visited a local winery,?Black Star Farms?where owner?Don Coe pointed to his still and said, ?That?s what does it. We should have a taste.?

?It? was grappa. ?It? was pear and oak-aged apple brandy. And ?it? was heaven, made from the fruit of the state my mother was born in, where my grandma was to be buried two days hence. Hemingway camped and fished just to the southwest on Walloon Lake, the setting of some of his first stories. Fruit grown in the sandy sloping soil?on the peninsula of Traverse City is superlative. Apples and pears and grapes raised in a climate made temperate by the largest bodies of fresh water on the planet. Michigan fruit is transformed into not only apple and pear brandy and grappa but also, what they?re known for, white wines in the Riesling style as well as incredibly big reds, such as the Cab Franc Merlot served at the Pigstock fund-raiser dinner. The region is also home to extraordinary local beer. Beer and wine and spirits to be taken seriously, worldwide, as far as I?m concerned.

I didn?t need to love Europe because it made great food, food close to my soul, I just needed to live long enough for America to figure out that we could make it ourselves out of our own ? [intone heavy French accent] ??terroir. The wine sucked at first, what we made here. You can?t just make great things right off the bat. Quality takes time, trial and error, thinking, but we?re doing it, and I know of no better model than Traverse City, which serves as a great example of what?s possible, producing extraordinary products from what grows best in the region. Can we make great wines in Ohio? Remains to be seen. Can we make great beer? You bet. Can we make great cassoulet? Oh yeah.

(But you know what, I can?t get?Michigan grappa in Cleveland because of our stupid State Liquor Board Control, which must list it before it?s allowed to be shipped in; they let one shitty grappa in, that?s it. Can we ship all government officials, House of Reps first aboard, to Australia and have a Thomas Jefferson do-over?)

Today?s Friday post is a digestif, rather than a cocktail, which is customarily taken after a meal, enhanced with tobacco if you partake.

If you?re looking for a Friday evening pre-meal cocktail,?go here.

Regardless, appreciate and encourage the bounty of this astonishing country. Preferably while you?re enjoying a a good martini or a post-meal eau de vie.

Other links you may like:

  • Cherry Capital Foods, an off-shoot of Earthy Delights (which I love), works to distribute locally grown products to restaurants and customers within a 150-mile radius of the farms.
  • My recent posts covering these cocktails: The Southside, Between the Sheets, and ?The Bloody Mary.
  • How do they get those pears in the bottle? Video one and two from Black Star Farms.
  • Check out these other?Michigan Wineries:?Left Foot Charley,?Chateau Chantal,?Chateau Grand Traverse,?L. Mawby, and?Old Mission?Peninsula,?to name a few.
  • Be sure to check out my upcoming events in Cleveland at the Fabulous Food Show and the West Side Market Centennial.
  • Learn about Peruvian Pisco, a grape-based brandy.

? 2012 Michael Ruhlman. Photo ? 2012 Donna Turner Ruhlman. All rights reserved.

?

Source: http://ruhlman.com/2012/10/michigan-italy-ohio-france/

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Kremlin dismisses talk Putin has back trouble

MOSCOW (Reuters) - The Kremlin on Thursday dismissed talk that Russian President Vladimir Putin has a back problem that prompted him to postpone foreign visits and might require surgery.

Putin, who began a six-year presidential term in May and turned 60 on October 7, was seen to be limping at an Asia-Pacific summit in the Pacific port of Vladivostok in early September.

Putin, a former KGB officer who enjoys vast authority at the head of Russia's so-called 'vertical' power structure, has long cultivated a tough-guy image that wouldn't sit well with a lengthy period on sick leave.

Three government sources have told Reuters in recent days that Putin was suffering from back trouble. One said it would require surgery in the near future.

Sources said the Russian leader's schedule was being cleared for early November, including through postponement until late December of a trip to India that had been expected soon.

"This does not correspond to reality," Putin's spokesman Dmitry Peskov told Reuters. He said Putin did not have a back problem and did not plan to take time off.

"You can see that he is having daily meetings," Peskov said. He said the earlier limp had been a "sports injury".

Putin did not travel to Pakistan for a planned four-nation summit on Afghanistan earlier this month and did not make an expected trip to Turkey. One source said Medvedev was expected to travel to Turkmenistan in Putin's stead next week.

"The chief is not well," said one of the sources, who spoke on condition of anonymity. Another said Putin had been seen recently wearing a back brace.

"No one has announced this formally, but everyone knows that foreign visits are being canceled because of his illness," one said.

Peskov denied the visits had been canceled. He said the visit to India would take place on the set date in late December and "no other dates have been officially announced".

HEALTHY IMAGE

A judo black belt, Putin has in recent years been filmed riding bare-chested on a horse, diving in the Black Sea, skiing in the Caucasus and fighting wildfires from an airplane.

His apparent fitness helped bring him early popularity because of the stark contrast with predecessor, Boris Yeltsin, who was sometimes drunk in public and had heart surgery when president in 1996.

Putin's formal role as head of state and his position at the pinnacle of power in Russia, where his blessing is seen as indispensable for everything from legislation to oil deals, makes any illness or medical treatment highly sensitive.

At a meeting with foreign analysts and journalists at his residence outside Moscow on Thursday, he did not appear to be in pain but, as in other recent public appearances, leant forward in his seat, putting weight on his right forearm.

At the Asia-Pacific summit in Vladivostok in September, he was also caught by TV cameras complaining to Foreign Minister Sergei Lavrov that he was on restricted diet.

The summit followed an episode in which Putin flew in a delta-winged light aircraft with a flock of cranes that had been bred in captivity, in an attempt to train them to migrate.

At the time, Peskov said that Putin had pulled a leg muscle but that he had not sustained the injury in the crane flight.

In power as Russia's president or prime minister since 1999, Putin could remain in the Kremlin until May of 2024, when he would be 71 years old, if he seeks and wins re-election in 2018.

His election to a new term in March after four years as prime minister followed the biggest opposition protests of his rule, prompted by suspicions of fraud in a December 2011 parliamentary election won by his ruling United Party.

(Writing by Gleb Bryanski and Douglas Busvine; Editing by Steve Gutterman and Will Waterman)

Source: http://news.yahoo.com/kremlin-dismisses-talk-putin-back-trouble-204302300.html

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Friday, October 26, 2012

Better Farm: Top Survival Downloads

?Preppers Network has prepared this spectacular list of top 10 survival downloads everyone should have.?

Really. Everyone.?

Here's a reprint of the article:

Top 10 Survival Downloads You Should HaveThe following article has been generously contributed for your reading pleasure by Rourke at Modern Survival Online. We strongly urge our readers to take Rourke?s advice and download or print (or both) the following guides, which are available 100% free. Ideally, retain a paper copy if you have a survival folder, and save a copy to your reserve USB drive, which should be a component of your bug out survival bag or stored at your bug out location.




There are tons of good downloads in the Survival Database Download section of this website. For this article ? I have selected 10 that everyone should have either printed and put away, or placed on a USB drive ? or better yet both. So ? let?s get to it:

#10. FM 4-25-11 First Aid (2002) ? Military First Aid Manual.First aid information is a must ? get training before you need it ? use this manual for reference.

#9. Guide to Canning ? Being able to preserve crops to be able to provide for yourself and your family long after the growing season is over is important. This guide will help with that.

#8. Rangers Handbook (2006) ? Crammed with info on demolitions, booby traps, communications, patrolling, tactical movement, battle drills, combat intelligence and much more.

#7. Where There is No Dentist ? The author uses straightforward language and careful instructions to explain how to: examine patients; diagnose common dental problems; make and use dental equipment; use local anesthetics; place fillings; and remove teeth.

#6. NATO Emergency War Surgery ? While this is certainly not a manual that would stand alone in most persons emergency/disaster library, it is an absolutely necessary resource if you expect to handle any type of trauma where immediate comprehensive medical care is not available.

#5. A Guide to Raised Bed Gardening ? This is not an ?all knowing? gardening book ? however it provides a lot of information to the ?urban gardener? before or after TSHTF. Best to get the experience and knowledge of gardening NOW rather than later.

#4. FM 3-06 Combined Arms Operations in Urban Terrain ? Combat techniques covered in the manual which may be very valuable in a ?Roadwarrior?-type world.

#3. 1881 Household Cyclopedia ? A massive resource of information that much of it has been lost over the past 203 generations. From Angling to Knitting ? its here.

#2. FM 21-76-1 Survival-Evasion-Recovery (1999) ? Excellent manual geared towards the soldier that finds himself behind enemy lines.

#1. FM 21-76 US Army Survival Manual ? From Amazon.com: This manual has been written to help you acquire survival skills. It tells you how to travel, find water and food, shelter yourself from the weather and care for yourself if you become sick or injured. This information is first treated generally and then applied specifically to such special areas as the Arctic, the desert, the jungle and the ocean.1970 Military Issue Manual. General Introduction and Individual and Group Survival Orientation Navigation, Finding Water In All Parts of The Globe. How To Obtain Food, Start a Fire and much more!

Well, there?s my list. Best of all ? they are all 100% free. So, feel free to download them all.?Rourke


Source: http://blog.betterfarm.org/2012/10/top-survival-downloads.html

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Jon Stewart on When to Pick Winners and Losers

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Lena Dunham's 'first time' subject of Obama ad

By Sophie A. Schillaci , The Hollywood Reporter

Lena Dunham remembers her first time.?Voting, that is.?The "Girls"creator and star is encouraging young females to get out to the polls and vote for "a great guy."

PHOTOS: Young Hollywood's secret breakfast with Obama

"Your first time shouldn't be with just anybody," she says, before listing various qualities that ladies should look for in their ideal candidate. Among them: "someone who really cares about and understands women," "a guy who cares whether you get health insurance and specifically whether you get birth control -- the consequences are huge," and someone who believes that same sex couples should be able to have "beautiful, complicated weddings like the kinds we see on Bravo and TLC all the time."

"Think about how you want to spend those four years," she challenges. "In college-age time, that's 150 years."

At the end of the one-minute ad, Dunham recalls coming of age during her first time at the polls, where she voted for Barack Obama.

PHOTOS: The top celebrity political Twitter commentators

The outspoken, politically liberal Dunham drew criticism this week for joking with Mindy Kaling and B.J. Novak about dressing for Halloween as the Canadian couple convicted of murder and rape in the '90s.

"You guys go as killer Canadian couple Paul Bernado and Karla Homolka. I'll be her sister they murdered. Scariest!" she posted in a tweet that has since been removed.

Dunham addressed her campaign video on Twitter Thursday, writing, "My first time was with @BarackObama -- I highly recommend you do the same."

She added, "The video may be light but the message is serious: vote for women's rights."

Related content:

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Source: http://todayentertainment.today.com/_news/2012/10/26/14718043-lena-dunham-stumps-for-obama-in-ad-about-her-first-time-voting?lite

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Jefferson Parish Sheriff's Office West Bank crime report, Oct. 24 ...

This information reflects initial calls for service reported by the Jefferson Parish Sheriff's Office for the west bank of Jefferson Parish. Locations are approximate due to automated location methods and address inconsistencies, the Sheriff's Office says. Burglar alarm calls are excluded.


13th Street and Avenue A - Oct. 24, 8:35 a.m., suspicious person.
2nd Avenue and 7th Street - Oct. 24, 8:01 a.m., vehicle wreck.
1200 block of Aberdeen Drive - Oct. 24, 11:23 a.m., battery.
Acre Road and Ames Boulevard - Oct. 24, 4:03 p.m., battery.
1100 block of Ames Boulevard - Oct. 24, 1:08 a.m., theft.
Ames Boulevard and 4th Avenue - Oct. 24, 7:49 p.m., suspicious person.
Ames Boulevard and East Ames Boulevard - Oct. 24, 12:18 a.m., suspicious person.
Ames Boulevard and Ehret Road - Oct. 24, 4:59 p.m., suspicious person.
Ames Boulevard and Rue Jesann Street - Oct. 24, 6:23 a.m., suspicious person.
Avenue A and Westbank Exp - Oct. 24, 7:53 p.m., disturbing the peace.
1200 block of Avenue D - Oct. 24, 1:47 a.m., battery.
1200 block of Barataria Boulevard - Oct. 24, 2:39 p.m., theft.
600 block of Barataria Boulevard - Oct. 24, 6:54 p.m., business burglary.
Barataria Boulevard and Bergeron Court - Oct. 24, 12:32 a.m., suspicious person.
Barataria Boulevard and Westbank Exp - Oct. 24, 9:04 p.m., suspicious person.
900 block of Beechgrove Boulevard - Oct. 24, 3:20 p.m., suspicious person.
Behrman Highway and South Monterey Court - Oct. 24, 1:15 p.m., suspicious person.
2700 block of Belle Chasse Highway - Oct. 24, 6:28 p.m., suspicious person.
Belle Chasse Highway and Lapalco Boulevard - Oct. 24, 10:06 a.m., suspicious person.
100 block of Blanche Drive - Oct. 24, 7:09 a.m., suspicious person.
1100 block of Blk Candlelight Drive - Oct. 24, 10:45 p.m., illegal discharge of weapon.
500 block of Blk Cohen Avenue - Oct. 24, 10:27 a.m., suspicious person.
2500 block of Blk Lapalco Boulevard - Oct. 24, 1:45 p.m., suspicious person.
3000 block of Blk Lapalco Boulevard - Oct. 24, 8:56 a.m., suspicious person.
1100 block of Blk Medical Center Boulevard - Oct. 24, 1:11 a.m., suspicious person.
500 block of Blk Terry Parkway - Oct. 24, 5:01 p.m., vehicle wreck.
Chenevert Road and South Kenner Road - Oct. 24, 7:48 p.m., suspicious person.
1100 block of Cohen Avenue - Oct. 24, 7:31 p.m., suspicious person.
Crestridge Cir and Ehret Road - Oct. 24, 7:48 a.m., suspicious person.
10 Davenport Street - Oct. 24, 12:53 p.m., suspicious person.
3200 block of Destrehan Avenue - Oct. 24, 7:42 a.m., theft.
Destrehan Avenue and Lapalco Boulevard - Oct. 24, 11:09 a.m., drug law violation.
Destrehan Avenue and Liro Lane - Oct. 24, 12:06 a.m., suspicious person.
Destrehan Avenue and Liro Lane - Oct. 24, 3:47 p.m., suspicious person.
Destrehan Avenue and Sandy Lane - Oct. 24, 4:43 p.m., suspicious person.
Destrehan Avenue and Sandy Lane - Oct. 24, 4:51 p.m., suspicious person.
100 block of Dexter Drive - Oct. 24, 1:09 p.m., theft.
1000 block of Di Marco Drive - Oct. 24, 10:53 a.m., disturbing the peace.
3800 block of Eastview Drive - Oct. 24, 2:26 p.m., suspicious person.
1800 block of Estalote Avenue - Oct. 24, 4:22 a.m., suspicious person.
1900 block of South Forest Lawn Drive - Oct. 24, 5:35 p.m., suspicious person.
700 block of Gladstone Court - Oct. 24, 5:37 a.m., vehicle wreck.
2100 block of Grape Place - Oct. 24, 4:24 p.m., residence burglary.
Hector Avenue and Terry Parkway - Oct. 24, 8:07 p.m., suspicious person.
Highway 90 and Lapalco Boulevard - Oct. 24, 8:23 p.m., suspicious person.
4000 block of Hillcrest Drive - Oct. 24, 3:23 p.m., vehicle burglary.
700 block of Hinyub Avenue - Oct. 24, 9:32 p.m., illegal discharge of weapon.
2600 block of Jean Lafitte Boulevard - Oct. 24, 10:57 a.m., vehicle wreck.
600 block of Jean Lafitte Boulevard - Oct. 24, 11:08 a.m., suspicious person.
200 block of Jeffer Drive - Oct. 24, 9:04 p.m., residence burglary.
5500 block of Jordan Drive - Oct. 24, 9:26 a.m., disturbing the peace.
South Judah Drive and Ames Boulevard - Oct. 24, 7:32 p.m., suspicious person.
2800 block of Keith Way Drive - Oct. 24, 2:05 p.m., suspicious person.
2800 block of Keith Way Drive - Oct. 24, 8:25 p.m., vehicle wreck.
4200 block of Lac Bienville Drive - Oct. 24, 4:15 p.m., residence burglary.
2300 block of Lafayette Avenue - Oct. 24, 10:46 p.m., suspicious person.
900 block of Lamar Avenue - Oct. 24, 9:04 a.m., theft.
900 block of Lamar Avenue - Oct. 24, 1:35 p.m., battery.
800 block of Lander Street - Oct. 24, 7:52 p.m., disturbing the peace.
100 block of Lapalco Boulevard - Oct. 24, 8:25 p.m., disturbing the peace.
1600 block of Lapalco Boulevard - Oct. 24, 6:20 p.m., theft.
1600 block of Lapalco Boulevard - Oct. 24, 7:46 p.m., disturbing the peace.
3600 block of Lapalco Boulevard - Oct. 24, 6:04 a.m., vehicle wreck.
4800 block of Lapalco Boulevard - Oct. 24, 7:48 p.m., suspicious person.
6500 block of Lapalco Boulevard - Oct. 24, 2:16 p.m., suspicious person.
6500 block of Lapalco Boulevard - Oct. 24, 2:23 p.m., drug law violation.
7200 block of Lapalco Boulevard - Oct. 24, 11:44 a.m., disturbing the peace.
7200 block of Lapalco Boulevard - Oct. 24, 12:14 p.m., battery.
Lapalco Boulevard and Behrman Highway - Oct. 24, 1:28 p.m., suspicious person.
Lapalco Boulevard and Berger Road - Oct. 24, 5:19 p.m., vehicle wreck.
500 block of Lester Street - Oct. 24, 10:45 a.m., criminal damage.
Longleaf Lane and Max Drive - Oct. 24, 4:02 p.m., suspicious person.
1500 block of Lorene Drive - Oct. 24, 3:45 p.m., disturbing the peace.
1500 block of Lorene Drive - Oct. 24, 8:45 p.m., disturbing the peace.
Mac Arthur Avenue and Westbank Exp - Oct. 24, 12:08 p.m., suspicious person.
1500 block of Manhattan Boulevard - Oct. 24, 11:42 a.m., theft.
1500 block of Manhattan Boulevard - Oct. 24, 2:08 p.m., theft.
1700 block of Manhattan Boulevard - Oct. 24, 4:29 p.m., suspicious person.
1700 block of Manhattan Boulevard - Oct. 24, 10:51 p.m., suspicious person.
600 block of Manhattan Boulevard - Oct. 24, 8:45 a.m., vehicle wreck.
Manhattan Boulevard and 8th Street - Oct. 24, 12:44 p.m., suspicious person.
Manhattan Boulevard and Lapalco Boulevard - Oct. 24, 12:48 a.m., suspicious person.
Manhattan Boulevard and Lapalco Boulevard - Oct. 24, 6:51 a.m., suspicious person.
Manhattan Boulevard and Pine Street - Oct. 24, 8:10 a.m., vehicle wreck.
Manhattan Boulevard and Westbank Exp - Oct. 24, 1:05 a.m., suspicious person.
2600 block of Max Drive - Oct. 24, 3:44 p.m., suspicious person.
700 block of Morningside Drive - Oct. 24, 8:33 a.m., residence burglary.
600 block of Oak Avenue - Oct. 24, 3:53 p.m., suspicious person.
2400 block of Oxford Place - Oct. 24, 7:39 a.m., theft.
3900 block of Post Drive - Oct. 24, 10:27 p.m., residence burglary.
Post Drive and Deerlick Lane - Oct. 24, 1:52 p.m., suspicious person.
Promanade Boulevard and Lapalco Boulevard - Oct. 24, 3:51 p.m., vehicle wreck.
500 block of Rene Street - Oct. 24, 12:16 a.m., disturbing the peace.
Rene Street and Gwen Street - Oct. 24, 6:58 p.m., suspicious person.
100 block of Rosalie Drive - Oct. 24, 7:50 p.m., disturbing the peace.
7300 block of Runnymede Drive - Oct. 24, 10:06 p.m., battery.
200 block of Senate Drive - Oct. 24, 5:00 p.m., criminal damage.
3000 block of Sienna Drive - Oct. 24, 11:11 a.m., suspicious person.
Sweet Bay Lane and Rivet Boulevard - Oct. 24, 11:13 p.m., suspicious person.
1000 block of Tallow Tree Lane - Oct. 24, 11:52 p.m., suspicious person.
500 block of Terry Parkway - Oct. 24, 8:59 a.m., vehicle wreck.
600 block of Terry Parkway - Oct. 24, 8:21 p.m., theft.
Terry Parkway and Westbank Exp - Oct. 24, 11:26 a.m., suspicious person.
4200 block of Teton Street - Oct. 24, 11:17 a.m., vehicle wreck.
5000 block of Towering Oaks Avenue - Oct. 24, 8:07 p.m., disturbing the peace.
600 block of Wall Boulevard - Oct. 24, 3:33 p.m., suspicious person.
Wall Boulevard and Lapalco Boulevard - Oct. 24, 8:31 a.m., suspicious person.
Wall Boulevard and North Carlisle Drive - Oct. 24, 3:49 a.m., suspicious person.
100 block of Westbank Exp - Oct. 24, 3:28 p.m., theft.
Westbank Exp and Ames Boulevard - Oct. 24, 5:46 p.m., vehicle wreck.
Westbank Exp and Brown Avenue - Oct. 24, 8:40 a.m., suspicious person.
500 block of Westwood Drive - Oct. 24, 9:18 p.m., vehicle burglary.
Wichers Drive and Avenue B - Oct. 24, 11:39 a.m., suspicious person.
500 block of Willowbrook Drive - Oct. 24, 1:08 p.m., criminal damage.
2000 block of Woodmere Boulevard - Oct. 24, 7:39 a.m., suspicious person.
2400 block of Woodmere Boulevard - Oct. 24, 12:25 a.m., suspicious person.
2400 block of Woodmere Boulevard - Oct. 24, 4:26 p.m., suspicious person.
1100 block of Wright Avenue - Oct. 24, 11:54 a.m., suspicious person.
Wright Avenue and Cooper Road - Oct. 24, 2:32 p.m., suspicious person.

Source: http://www.nola.com/crime/index.ssf/2012/10/jefferson_parish_sheriffs_offi_1107.html

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Hurricane Sandy as the October election surprise?

As Hurricane Sandy heads toward land on the East Coast, the storm and its aftermath could lend an interesting twist to the upcoming general election?call it the ?October surprise??as some power outages could last into Election Day.

sandyHurricane Sandy?s track is projected to directly affect two swing states in the election?Pennsylvania and Virginia?with Ohio also in the storm?s path inward.

The storm will arrive about a week before Election Day, and widespread, long-term power outages are a possibility, based on recent trends and the severity of the storm.

With President Barack Obama and Mitt Romney on center stage next week, the storm?s aftermath could affect voting logistics, travel, and even the volume of campaign TV advertising.

The concept of the October surprise in presidential elections dates back to the 1968 campaign, when President Lyndon Johnson stopped bombing in the Vietnam War as a way to help Democratic candidate Hubert Humphrey.

Ronald Reagan also worried about a late surprise in the 1980 election, when there were rumors that President Jimmy Carter was working to free hostages in Iran just days before the election.

Recent Constitution Daily Stories

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However, a major weather event as the October surprise just a week before the contest between President Obama and Mitt Romney would be unique, and it shouldn?t be discounted.

Hurricane Sandy is now off the Atlantic Coast and heading up from Florida toward the Mid-Atlantic and New England regions. Meteorologists say over the weekend, Sandy will meet up with another storm and then make a sharp-left turn into a coastal region starting on Monday.

The center of the storm?s projected path is southern New Jersey, but its eye could make landfall in an area between Virginia and Connecticut.

The storm is so wide that it will likely bring severe conditions to an area inhabited by 66 million people, including parts of North Carolina, Virginia, West Virginia, Ohio, Pennsylvania, New Jersey, Delaware, Maryland, the District of Columbia, New York, and Connecticut.

These regions will see heavy rains and high winds, and areas in the northwest track of the storm may see snow.? It all adds up to a recipe for massive power outages, storm damage, and flooding.

On his blog, AccuWeather Enterprise Solutions vice president Michael Smith says widespread power outages are very likely possible.

?Because of the geographic extent (winds capable of causing power failures in a swath hundreds of miles in width), there could be massive power failures and, once out, the power may be out for weeks,? Smith.

In August 2011, Hurricane Irene left millions of utility customers without power at some point. Half of those power outages were in Virginia, New Jersey, and Pennsylvania.

The Department of Energy says the peak number of power outages during Hurricane Irene was about 5.9 million on the night of August 28, with about 3 million outages in Virginia, Maryland, Pennsylvania and New Jersey. Five days later, about 580,000 people were still without power.

So in October 2012, Hurricane Sandy won?t make an exit until November 1, leaving power crews about five or six days to get people back on the grid, including polling places, public buildings and residences.

Two states that depend heavily on electronic voting are Pennsylvania and Virginia. They also don?t have early voting.

Ohio will also be affected by Hurricane Sandy and some meteorologists are forecasting snow for parts of eastern Ohio.

On Thursday, the Christian Science Monitor reported there were already concerns about the electronic voting systems in Virginia and Pennsylvania before Hurricane Sandy became an issue.

?In four key battleground states?Pennsylvania, Virginia, Florida, and Colorado?glitches in e-voting machines could produce incorrect or incomplete tallies that would be difficult to detect and all but impossible to correct because the machines have no paper record for officials to go back and check,? the Monitor said in its exclusive report.

The newspaper said in Pennsylvania, 50 of 68 counties use paperless voting systems, while in Virginia, 127 of 135 counties use paperless systems. And those electronic systems need electricity to operate.

In addition to potential voting machine problems, the fallout from storm damage and prolonged power outages could keep some people from the polls.

And in an ironic twist, television stations that broadcast to the Virginia market and even in Ohio might have a much greater chance to run more political advertisements on TV.

Local TV stations usually switch wall-to-wall storm coverage during big weather events, often pre-empting national TV programming. That would give stations more ad spots to run for candidates, in a more-high profile position?and at a much-higher cost.

The major impact of the storm will also give President Obama and Mitt Romney chances to act presidential in public.

There?s always a chance that Hurricane Sandy could be a dud, but that seems highly unlikely. The two major weather models used by forecasters agree the Sandy will make that left turn and run into the East Coast at some point.

Official forecasters also say there is a 90 percent chance that Hurricane Sandy will hit the East Coast.

Scott Bomboy is the editor-in-chief of the National Constitution Center.

Also Read

Source: http://news.yahoo.com/hurricane-sandy-october-election-surprise-160031906.html

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Sprint releases push-to-talk app for Android

Android Central

Sprint has launched an Android app to allow push-to-talk on some phones. The Kyocera Rise budget phone will support it, as will the upcoming LG Optimus Elite, it said.

Push-to-talk is a transmission method that turns your phone into a walkie-talkie, of sorts. The type that only allows communication one-way at a time, so like an air traffic controller, you’ll have to say “over” after each sentence, and of course “over and out” when your conversation is done.

For cell users, push-to-talk cellular is supposed to give people a way to quickly broadcast a message to receiving handsets. If multiple handsets are hooked up, a team leader can speak to all of them without ringing each one up individually.

Some apps already emulate this function, like HeyTell and Zello, but the Sprint app uses the carrier’s Direct Connect push-to-talk service. Sprint says it has a million users on Direct Connect already (most on rugged handsets), and hopes the app will allow it to tap into a new user-base.

Sprint customers can hit the Google Play link above to download the app.



Source: http://feedproxy.google.com/~r/androidcentral/~3/41jE35AVwyc/story01.htm

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Snooki 'Was Really Pissed' With 'The Situation'

'Jersey Shore' star tells MTV News that Mike Sorrentino 'needed to work' for her forgiveness on Thursday night's reconciliation.
By Christina Garibaldi


Snooki
Photo: MTV News

Source: http://www.mtv.com/news/articles/1696285/jersey-shore-snooki-mike-the-situation-relationship.jhtml

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What Fears Are Holding Your Small Business Back? | Small ...

Halloween is almost here and creepy things are everywhere. It?s the time of year when we enjoy a good fright. But are there other (not-so-fun) fears holding your small business back from getting where you want it to go?

One of the joys of running your own business is that you get to decide what happens next. You don?t have to do what a boss is telling you. But sometimes, that can backfire if you avoid doing things that make you scared or uncomfortable. Yes, you may be able to get your business to a certain level of success without ever facing your demons. But if you want to achieve breakthrough growth, you need to push past the fears that are holding you back.

business fear

What kinds of fears are you facing (or failing to face)?

Below?are some common ones:

Fear Of Technology

Technology moves so fast today that sometimes it?s tempting to just throw up your hands and say, ?I?ll never get up to speed.? Well, your business can?t afford that attitude. Even if you?re a dyed-in-the-wool technophobe, you need to get over it, because today technology is essential to give your small business an edge.

Start by hiring someone (inside or outsourced) who knows the stuff you don?t and can get your company up to speed. If you must, take a class (online or off) to learn the basics. Enlist a patient friend to tutor you. Anything that gets you comfortable with what you need to know.

Fear Of Sales

This is a huge one for lots of entrepreneurs, myself included. When we first started our business, I struggled with fears of seeming pushy, aggressive or money-grubbing when I went out to ask for the sale. I wish I could tell you there?s some easy formula for getting over this fear, but there isn?t.

I just had to do it over and over, until it got easier (I didn?t say easy). Practice makes (almost) perfect.

Fear Of Being A Boss

When your company is young and small, it?s easy to feel like you and your tiny team are pretty much equals, and that?s more comfortable for many entrepreneurs who don?t want to be perceived as the distant ?boss-man.? However, as your business grows, you?ll have to distance yourself a bit so you can take on sometimes scary tasks like making unpopular decisions, or disciplining employees who aren?t working out.

I?m not saying you can?t be a nice, friendly boss, but acknowledging that you are the boss is a crucial step in getting your business to the next level.

Fear Of Networking

It?s easier than ever to network through social media today, and many of us are great at that. But you also need to go offline sometimes and get up close and personal. Networking has earned an unfortunate reputation as phony ?schmoozing,? but in reality, it?s how relationships are built and business is done.

Make sure you invite your online connections out for coffee or lunch on a regular basis, attend networking events and industry conferences, and generally put yourself out there. If you?re shy (like I am), start with things in your comfort zone (like coffee with one person) and move up to the big leagues gradually?but do move up, or your business won?t.

Fear Of Success

When you get stuck in the day-to-day running your business and making payroll, sometimes your sights get set too low. Do that long enough, and you may decide it?s not worth dreaming big because you?ll never get there anyway.

That?s the surest route to business stagnation and a ho-hum life. To paraphrase Oscar Wilde, take your eyes off the ground and make time to look at the stars.

Fear Photo via Shutterstock


About Rieva Lesonsky

Rieva Lesonsky Rieva Lesonsky is CEO of GrowBiz Media, a media company that helps entrepreneurs start and grow their businesses. Visit her blog, SmallBizDaily. Visit her website SmallBizTrendCast to get the scoop on business trends and sign up for Rieva?s free TrendCast reports.

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Source: http://smallbiztrends.com/2012/10/fear-holding-your-small-business-back.html

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Italy bans Novartis flu vaccines pending tests

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Lactation protein suppresses tumors and metastasis in breast cancer

ScienceDaily (Oct. 24, 2012) ? A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology.

"This is the first confirmed report that this protein, called Elf5, is a tumor suppressor in breast cancer," explains Satrajit Sinha, PhD, associate professor of biochemistry in the UB School of Medicine and Biomedical Sciences and a corresponding author on the paper with Yibin Kang, PhD, in the Department of Molecular Biology at Princeton University.

The researchers say the findings provide new avenues to pursue in treating and diagnosing breast cancer and possibly cancers of other organs as well. The paper includes findings from both animal and human breast cancer models.

Under normal circumstances, Elf5 is a transcription factor that controls the genes that allow for milk production.

But when the researchers used knockout mice developed at UB, in whom Elf5 was removed, they found more than just an inability to produce milk. They found that epithelial cells in the mammary glands also became more mesenchymal, that is, more like stem cells, an early harbinger of cancer, Sinha says.

"We found that when Elf5 levels are low or absent, epithelial cells become more like stem cells, morphing into mesenchymal cells, changing their shape and appearance and migrating elsewhere in the body," says Sinha. "This is how cancer spreads."

The UB-Princeton collaboration began when lead author Rumela Chakrabarti, PhD, originally a postdoctoral researcher in Sinha's laboratory at UB, took a position in the laboratory of Yibin Kang, PhD, Warner-Lambert/Parke-Davis Professor of Molecular Biology at Princeton, whose research focus is breast cancer metastasis. This allowed Chakrabarti to harness the expertise of the two laboratories to generate such a breakthrough finding.

"Elf5 keeps normal breast cells in their current shape and restricts their movement," says Chakrabarti. She found that the protein accomplishes this by suppressing the epithelial-mesenchymal transition by directly repressing transcription of Snail2, a master regulator of mammary stem cells known to trigger the EMT.

"Elf5 keeps Snail2 repressed, but once Elf5 is lost, then there is nothing to repress Snail 2," she explains.

The paper notes that Elf5 loss is frequently detected early in the disease at the breast hyperplasia stage, when the number of cells increases. In experiments conducted by the Princeton scientists, the researchers also found that little or no Elf5 in human breast cancer samples correlated with increased morbidity.

"It seems that loss of Elf5 is an initial event in the disease, so it could also be an important diagnostic tool," Sinha notes, which is a current focus of the UB and Princeton team.

"We want to know, how early does the loss of Elf5 occur? Could we use loss of Elf5 as a reliable diagnostic tool?" he asks.

The finding reveals the complex pathways through which breast cancers develop, he says, while also providing new avenues to pursue for diagnostics and treatments.

"Our research shows that the EMT-Snail 2 pathway is a valuable one to target for early breast cancer intervention," says Sinha, "possibly by designing something to recapture the repressive effect of Elf5 or a drug that could mimic Elf5 activity. And this is just one molecule, part of a big network. That's why we are now creating a detailed map of this molecule and its associated partners in order to give us a better idea of what to look for."

Other UB co-authors on the paper are Rose-Anne Romano, PhD, research assistant professor in biochemistry, and Kirsten Smalley, research technician. Other coauthors are: Julie Hwang, Mario Andres Blanco, Martin Lukacisin and Yong Wei from Princeton; Song Liu of Roswell Park Cancer Institute; Qifeng Yang and Bruce F. Haffty of the Department of Radiation Oncology in the University of Medicine and Dentistry of New Jersey and the Cancer Institute of New Jersey; and Toni Ibrahim, Laura Mercatali and Dino Amadori of the Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori in Italy.

The research was supported by the National Institutes of Health, the Department of Defense, Komen for the Cure, the Brewster Foundation and the Champalimaud Foundation.

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The above story is reprinted from materials provided by University at Buffalo, via Newswise.

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Journal Reference:

  1. Rumela Chakrabarti, Julie Hwang, Mario Andres Blanco, Yong Wei, Martin Luka?i?in, Rose-Anne Romano, Kirsten Smalley, Song Liu, Qifeng Yang, Toni Ibrahim, Laura Mercatali, Dino Amadori, Bruce G. Haffty, Satrajit Sinha, Yibin Kang. Elf5 inhibits the epithelial?mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nature Cell Biology, 2012; DOI: 10.1038/ncb2607

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/7X9jNEk8Njk/121024101531.htm

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