Sunday, March 31, 2013

Kidsquash Completes 8th Season with Smiles | Tariq Mohammed's ...

March 30, 2013 ? 11:21 pm

Since the 2004 pilot of Kidsquash, we marked the completion of the 8thKidsquash season with ten students from the Greater Boston community. They played in a friendly round robin under the supervision of Laura Gemmell, a Harvard senior and 4-time All-American on the women?s varsity squash team, Octavio Chiesa, a volunteer peer coach and myself.

Beginner junior squash players make progress at Kidsquash.

Beginner junior squash players make progress at Kidsquash.

From October 2012 to March 2013, Kidsquash students gathered for Saturday morning recreational squash clinics. Thanks to donations from the Harvard Athletics Department, we were able to recognize 4 students who are newcomers to the sport with Harvard squash apparel. These students were ? Megan Yoh (Best Female Player), Seamus Buckley (Most Improved Player), Will Gladstone (Most Valuable Player) and Samuel Esquivel (Sportsmanship Award).

Many thanks to Luke Hammond, Lead Coach for Kidsquash , Mike Way, Head Squash Coach at Harvard and Coach Bajwa, Founder of Kidsquash for their guidance and support of the program. Also, thank you to Kidsquash parents and sponsors for making it a great season!

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Source: http://tariqmohammed.wordpress.com/2013/03/30/kidsquash-completes-8th-season-with-smiles/

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Friday, March 29, 2013

Number Of Early Childhood Vaccines Not Linked To Autism

A new study from the Centers for Disease Control and Prevention finds no link between the number of vaccinations a young child receives and the risk of developing autism spectrum disorders.

Jeff J. Mitchell/Getty Images

A large new government study should reassure parents who are afraid that kids are getting autism because they receive too many vaccines too early in life.

The study, by researchers at the Center for Disease Control and Prevention, found no connection between the number of vaccines a child received and his or her risk of autism spectrum disorder. It also found that even though kids are getting more vaccines these days, those vaccines contain many fewer of the substances that provoke an immune response.

The study offers a response to vaccine skeptics who have suggested that getting too many vaccines on one day or in the first two years of life may lead to autism, says Frank DeStefano, director of the Immunization Safety Office of the CDC.

To find out if that was happening, DeStefano led a team that compared the vaccine histories of about 250 children who had autism spectrum disorder with those of 750 typical kids. Specifically, the researchers looked at what scientists call antigens. An antigen is a substance in a vaccine that causes the body to produce antibodies, proteins that help fight off infections.

The team looked at medical records to see how many antigens each child received and whether that affected the risk of autism. The results, published in The Journal of Pediatrics, were unequivocal.

"The amount of antigens from vaccines received on one day of vaccination or in total during the first two years of life is not related to the development of autism spectrum disorder in children," DeStefano says.

The finding came as no surprise to researchers who study the immune system, DeStefano says. After all, he says, kids are exposed to antigens all the time in the form of bacteria and viruses. "It's not really clear why a few more antigens from vaccines would be something that the immune system could not handle," he says.

The study also found that even though the number of vaccines has gone up, the number of antigens in vaccines has gone down markedly. In the late-1990s, the vaccination schedule exposed children to several thousand antigens, the study says. But by 2012, that number had fallen to 315.

That dramatic reduction occurred because vaccines have become much more precise in the way they stimulate the immune system, DeStefano says.

? The sad part is, by focusing on the question of whether vaccines cause autism spectrum disorders, [researchers are] missing the opportunity to look at what the real causes are. It's not vaccines.

Hardcore vaccine skeptics are unlikely to be swayed by the new research. But many worried parents should be, says Ellen Wright Clayton, a professor at Vanderbilt University who helped write a report on vaccine safety for the Institute of Medicine.

"I certainly hope that a carefully conducted study like this will get a lot of play, and that some people will find this convincing," Clayton says. That would let researchers pursue more important questions, she says.

"The sad part is, by focusing on the question of whether vaccines cause autism spectrum disorders, they're missing the opportunity to look at what the real causes are," she says. "It's not vaccines."

Autism Speaks, a major advocacy and research group, seems ready to move beyond the vaccine issue. Geraldine Dawson, the group's top scientist, praised the new study and says the result should clear the way for research on other potential causes of autism.

These include factors like nutrition, which can affect a baby's brain development in the womb, Dawson says. Other factors could include medications and infections during pregnancy, she says, or an infant's exposure to pesticides or pollution.

"As we home in on what is causing autism, I think we are going to have fewer and fewer questions about some of these things that don't appear to be causing autism," Dawson says.

Source: http://www.npr.org/blogs/health/2013/03/29/175626824/the-number-of-early-childhood-vaccines-not-linked-to-autism?ft=1&f=1007

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Thursday, March 28, 2013

Oil rises above $97, natural gas falls back

NEW YORK (AP) ? The price of oil rose above $97 a barrel Thursday for the first time in five weeks, boosted by gains in U.S. stock markets and more signs of a strengthening economy.

Benchmark oil for May delivery gained 65 cents to close at $97.23 a barrel in New York. Oil has gained nearly $5 per barrel in the past week, driven by encouraging economic indicators.

U.S. stocks set another record Thursday, as the Standard & Poor's 500 topped the closing high it set before the recession. The government said the U.S. economy grew at 0.4 percent in the fourth quarter, up from a previous estimate of 0.1 percent growth. And analysts think the economy is growing at a rate of around 2.5 percent in the current January-March quarter, which ends this week.

Oil's gains haven't yet factored into pump prices. The average price for a gallon of gas is $3.645, down from $3.65 a day earlier. Gas is now on average about 27 cents cheaper than a year ago.

Meanwhile the price of natural gas retreated, a day after it closed above $4 for the first time since Sept. 14, 2011. Natural gas futures fell 4 cents to end at $4.02 per 1,000 cubic feet. Natural gas has risen 67 cents, or 20 percent, this year as colder weather and greater use of natural gas for power generation have helped whittle away at a large surplus of the fuel in the U.S.

Brent crude, used to price many kinds of oil imported by U.S. refineries, was down 33 cents to finish at $109.38 a barrel on the ICE Futures exchange in London.

In other energy futures trading on the Nymex:

? Wholesale gasoline fell 1 cent to end at $3.11 a gallon.

? Heating oil was flat at $2.92 a gallon.

___

Pamela Sampson in Bangkok and Pablo Gorondi in Budapest contributed to this report.

Source: http://news.yahoo.com/oil-rises-above-97-natural-gas-falls-back-192135803--finance.html

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Google Glass Will Be Made In The U.S.A., Report Claims, At An Assembly Facility In Santa Clara

google glassGoogle Glass, the advanced head-mounted computing project the company is gearing up for a possible launch later this year, will be assembled in the U.S., according to a new report from the Financial Times today. The assembly will take place in a facility located in Santa Clara and managed by partner Hon Hai Precision, also known as Foxconn.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/u0Ka9cOPMco/

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New DNA test identifies ingredients in foods

Mar. 27, 2013 ? Almost all foodstuffs contain the genetic material of those animal and plant species that were used in their preparation. Scientists at the Institute of Molecular Genetics, Genetic Security Research and Consulting at Johannes Gutenberg University Mainz (JGU) have developed a novel screening procedure that provides for highly sensitive, quantifiable analysis of animal, plant, and microbial substances present in foodstuffs. For this, the researchers have adapted the latest techniques of DNA sequencing, which are otherwise currently employed in human genetics to unravel the genetic information of thousands of patients.

"The innovative aspect in comparison with conventional DNA detection methods such as polymerase chain reaction, or PCR for short, is that by means of bioinformatic analysis of all biological DNA data available worldwide we can identify the presence of material from species that we would not otherwise expect. And, using a simple digital method of counting short snippets of DNA, we will also probably be able to determine the relative incidence of individual species-related material more precisely than was previously the case," explained molecular geneticist Professor Dr. Thomas Hankeln, who developed the method in collaboration with bioinformaticist Professor Bertil Schmidt, Ph.D. and colleagues at the German and Swiss food control authorities.

In pilot studies, the researchers were able to use the new DNA method to detect the presence of a 1% content of horse meat in products and to determine the actual amount with a high level of precision. The Mainz researchers even found slight traces of the DNA of added mustard, lupin, and soy in a test sausage prepared for calibration purposes, something that could also be of interest with regard to allergy testing of foods.

Because of its potential, the method -- dubbed 'All-Food-Seq' by its developers -- has already attracted the attention of food inspection experts. "This method is very interesting in connection with efforts to promote the molecular traceability of food," said Hermann Broll of the German Federal Institute for Risk Assessment in Berlin and Dr. Ren? K?ppel of the Zurich Cantonal Laboratory in Switzerland. The method developed by the Mainz scientists is thus to be validated in comparison with conventional detection techniques in the near future.

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The above story is reprinted from materials provided by Universit?t Mainz.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/d3cVK4GL0Ts/130327092739.htm

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Tuesday, March 26, 2013

Bet on Your Baby: ABC Changes Premiere Date | canceled + ...

Bet On Your Baby The alphabet network has delayed the debut of their new Saturday night game show, Bet on Your Baby, by one week. It will now premiere on April 13th.

*** PREMIERE DATE CHANGE ***

IT?S A BOUNCING, BEAUTIFUL? GAME SHOW! ABC DELIVERS ?BET ON YOUR BABY? SATURDAY, APRIL 13, HOSTED BY MELISSA PETERMAN (?BABY DADDY,? ?DANCING FOOLS?)

Series to Be Co-Produced by Electus and 5?5 Media

All parents think they know their baby well, but are they willing to bet on it? ABC?s ?Bet On Your Baby? will reveal the answer to that question each week in an hour-long program featuring five memorable families with toddlers between the ages of two to three-and-a-half years old, who will play to see how well they can guess their child?s next move in the hopes of earning money towards their college fund. Actress/comedienne and working mom Melissa Peterman, star of ABC Family?s ?Baby Daddy? and ?Dancing Fools,? hosts ABC?s newest addition to the network lineup, the adorable, hilarious and surprisingly suspenseful game show, ?Bet on Your Baby,? which premieres with back-to-back episodes SATURDAY, APRIL 13 (8:00-9:00 & 9:00-10:00 p.m., ET).

Editor?s note: ?Bet on Your Baby? was originally scheduled to premiere on April 6.

On ?Bet on Your Baby,? the parents will be playing the game and the children will just be playing. The game takes place on two stages ? on one, a shiny game show studio with a cheering audience, one parent places a bet, while on the other, the parent takes the child to a play room called ?The Babydome? where the child determines the outcome of the game completely unaware of the stakes that are on the line. Each family plays a self-contained, individual challenge against the house ? meaning that they?re only competing against themselves, not against other families. Later on, the five families return to play for the chance to advance to the final round ? ?Smash for Cash? ? in which parents of one toddler will have 5 tries to hammer open piggy banks, one of which contains a $50,000 college fund.

?Episode 101? (8:00-9:00 p.m.) ? How many toys can your spouse get your toddler to clean up in a minute? How many cookies can your wife get your child to stack while time runs out? Which snack will your two-year-old choose to eat? ? And would you bet money on it?

?Episode 102? (9:00-10:00 p.m.) ? Will little Ryder be able to complete an obstacle course with Dad in just 90 seconds in the game ?Copycat?? Can young Addison name at least seven grocery items before the clock runs out during ?In the Bag,? and does she really know the word for ?corn,? as Dad insists but Mom doubts? And can Thomas play ?Stack ?Em? and not ?eat ?em? before time is up?

Co-creator and executive producer Craig Armstrong says: ??Bet On Your Baby? is an amazing way for parents to celebrate their babies and have a chance to win real money for their kids? college fund. It?s the happiest show on television.?

ABC has ordered eight episodes of the series, which is produced by some of the talents behind such hits as ?Supernanny,? ?Survivor,? ?The Biggest Loser? and ?Jamie Oliver?s Food Revolution.? ?Bet on Your Baby? was created by 5?5 Media?s Craig Armstrong, Rick Ringbakk, Charles Wachter and Electus? Ben Silverman and Jimmy Fox. The series is executive-produced by Electus (Ben Silverman, Chris Grant, Jimmy Fox) and 5?5 Media (Craig Armstrong and Rick Ringbakk). Electus International, the global distribution arm of Electus, will distribute the series universally.

About Electus

Electus is the first integrated multimedia entertainment studio to unite producers, creators, advertisers and distributors under one roof and produce all forms of content for distribution across a variety of platforms around the world. Headed by Ben Silverman in partnership with IAC [NASDAQ: IACI], the company connects advertisers, distributors and content creators early on in the development process, enabling marketers and advertisers to be a true partner in campaigns and content creation. Electus International, the global distribution arm of Electus, is responsible for all international sales and distribution for Electus? programming and its studio partners as well as programs and formats from other well-known 3rd party providers.

About 5X5 Media

Five by Five Media (?5?5?) is a full service television and film production company in an overall production and distribution agreement within the Electus studio system. 5?5 Media develops and produces both scripted and unscripted television programming and feature films. Its principals have won multiple primetime Emmy Awards and have produced such titles as ?Survivor,? ?The Amazing Race,? ?Jamie Oliver?s Food Revolution,? ?Supernanny? and ?Extreme Makeover: Home Edition.? 5?5?s recent productions include TBS? ?King of the Nerds,? SPIKE TV?s ?Car Lot Rescue,? CMT?s ?Jennie Garth: A Little Bit Country? and NBC?s fashion reality competition show, ?Fashion Star.?

?Bet on Your Baby? is broadcast in 720 Progressive (720P), ABC?s selected HDTV format, with 5.1-channel surround sound. A TV parental guideline will be assigned closer to airdate.

Source: http://tvseriesfinale.com/tv-show/bet-on-your-baby-abc-changes-premiere-date-27533/

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Monday, March 25, 2013

RolePlayGateway?

Im looking to start a Medieval/Fantasy role-play that will follow the exploits of a small group of around 5-8 people. They will be brought together for various personal agendas but share a overall goal. This wont be a dungeon crawl or free form rp, but more of an interactive narrative with the role-players writing the story. I know plenty of people do this, so I know that plenty of you can easily pull off this type of rp with little effort.

Things I Want To See
1. Since our cast will more than likely be small i want to see very well fleshed out characters. Think of habits and mannerisms, anything that will make your character truly one of a kind. The main problem that i have seen about characters is the lack of flaws. People tend to make their characters powerful and accomplished to begin with. While its fine to do this it doesn't leave any room for character growth, and no one wants to see a character that stays the same through the whole story. The key way to avoid this is not making young inexperienced characters, but to give your character flaws. Maybe they have insomnia and cant sleep because their dreams are plagued by sights from their past, or maybe they are a mage that is slowly losing their power. Its your choice, just dont make hugo-naught characters.

2. I want to see some powerful emotion within the group, and not the normal "Im a Knight and your a Rouge I hate you." sort of emotion, but true blue feelings. I wanna see conflicting interests and jealously, the group being divided at times and unsure of how to progress. Start a love triangle that pitts two people against each other and forces the one being fought over to choose one or neither. Maybe your character has a hidden agenda at the beginning but slowly begins to care for his companions. Dont treat this like a game but as if it were real, in reality how would you act or feel if it happened to you.

3. I would like to see some good character development as well. People change, and so should our characters. They make and loss friends, fall in and out of love, or change who they are altogether. Your character should at his/her core be mortal and as a mortal they will never be perfect. When your character is tested they dont always have to persevere, maybe they break under the pressure and they doubt who they are. Force them to re-evaluate who they are, giving them a mental dilemma that can make them stronger or change them. You should never be the same at the end as you were in the beginning.


Setting
It took me a while to decide on the setting but i finally managed to come up with one that offered a good starting foundation but also flexibility for the role-play.

The rp will take place in the Kingdom of Renaria which was once great and prosperous, but is now on a political and economical decline. To maintain its alliances and keep itself from a depression Renaria has sold its border territories and has offered fiefs to foreign dignitaries. Due to this many of its own noble houses have succumbed to poverty and hold a grudge towards the royalty. Also due to the lack of gold in the coffers Renaria has disbanded its standing military and reduced the number of guards in its cities. Because of the lack of protection and military presence most towns and wealthy citizens have turned to hiring private security forces and mercenaries.

Renaria was also a prime advocate of peaceful relations between Human, Elf, and Dwarf society. Because of this many cities grew a large population of Non-Human citizens, as well as pure Elf or Dwarf settlements. However without the presence of the military to deter those that would do them harm, many that detest the Non-Human have spoken out against them, sometimes leading to violent riots.


If anyone is interested, or if you have suggestions, please let me know.

Source: http://feeds.feedburner.com/RolePlayGateway

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Sunday, March 24, 2013

Indian company wins Almadar business support contract | Libya ...

Tripoli, ?23 March 2013:

Libyan mobile operator Almadar has awarded a contract to Indian financial software company Subex to provide it with a revenue assurance and fraud management system.

The Bangalore?based company, which provides business support systems for communications service providers, says it won the bid to provide its Revenue Operations Center (ROC) system in a competitive tendering process.

The system helps sustain profitable growth and sound financial health through a series of operations including revenue assurance, fraud management, credit risk management and inter-party settlement.

?We are taking a fresh approach to our business proposition and it was important to build the right ecosystem. As a first step, we have chosen the ROC Revenue Assurance and Fraud Management solutions from Subex?, said Jamal Hegag, chairman of Almadar. ?Subex?s experience in the global revenue and fraud management space is unparalleled and we are confident that this engagement will enable us to our business in a more effective manner?.

?Libya is an interesting telecom market with a lot of potential,? said Vinod Kumar, Chief Operating Officer, Subex. Our market leadership and strong domain capabilities in the area of Revenue Assurance and Fraud Management help us enable our customers to realize operational efficiencies and improve profits.?

Subex claims that ROC Revenue Assurance is ?the telecom industry?s first revenue assurance solution that simplifies RA?. It with the entire revenue chain and speeds up the process of revenue recovery.

ROC Fraud Management detects known fraud types as well as patterns of unusual behaviour, helps investigate these unusual patterns for potential fraud, and uses the knowledge, thus generated, to upgrade and protect against future intrusions.

Subex?s customers include 33 of the world?s 50 biggest telecommunications service providers worldwide.

?

Source: http://www.libyaherald.com/2013/03/23/indian-company-wins-almadar-business-support-contract/

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The Maintenance Mindset: Full-Service Oil Change At Bear ...

Full-Service Oil Change Grand Junction

Grand Junction people generally accept that many things in life require regular maintenance: their teeth, clothes, yards and so on, but CO motorists often don?t apply the idea of maintenance to their vehicles.

If you never brush your teeth or go to the dentist, you?ll become painfully aware of your neglect when you get a big cavity. Once the damage is done, we learn our critical lesson and start to take better care of things.

Unfortunately, Grand Junction people too often learn the hard automotive lesson when they bring their vehicle to Bear Automotive & RV Service Inc on a tow truck. So many times, a little routine maintenance would have prevented an expensive breakdown.

So how do Grand Junction motorists get into the habit of taking care of their minivans? It?s so easy to forget; not like cutting the grass which you see it every time you pull in the driveway.

Here?s something that will help: The key to good minivan maintenance starts with the oil change. Think about it ? when you go in for a full-service oil change in Grand Junction, your knowledgeable Bear Automotive & RV Service Inc technician will check all your fluids. If one of them is low, he can look for the reason why. If your serpentine belt is worn, he?ll see it and let you know. Corroded battery cable ? they?ve got you covered. And they?ll check to see if your manufacturer has recommended any critical services at your current mileage.

The oil change becomes kind of a focal point, a way to check in to see what needs to be done.

The fact is that vehicle inspection surveys consistently reveal that over 80% of vehicles have one or more unperformed repair or maintenance service. Vehicles are generally very reliable and can take a lot of abuse and neglect ? but you can only press your luck so long.

So when you come into Bear Automotive & RV Service Inc for an oil change, you get a visual inspection of your car and a reminder for recommended services so you can avoid a total failure. And remember that your technician can help you work out a maintenance and repair plan for your minivan, prioritizing and scheduling the work to make sure you and your family are safe, and avoid expensive breakdowns.

In addition to full-service oil changes, at Bear Automotive & RV Service Inc we also offer brake service, wheel bearing service and battery service.

Give us a call

Bear Automotive & RV Service Inc
970.245.2585
1315 Pitkin Ave
Grand Junction, CO 81501

At Bear Automotive & RV Service Inc in Grand Junction CO (81501) we install quality NAPA replacement parts. Give us a call at 970.245.2585. To learn more about NAPA AutoCare, visit www.NAPAAutoCare.com.

Source: http://bearautomotivervserviceinc.mynapatools.com/2013/03/22/the-maintenance-mindset-full-service-oil-change-at-bear-automotive-rv-service-inc/

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Gunmen seize Israeli, Norwegian tourists in Egypt's Sinai

CAIRO (Reuters) - Masked gunmen in Egypt's Sinai Peninsula kidnapped two tourists, an Israeli man and a Norwegian woman, travelling between two coastal resorts, Egyptian and Israeli officials said on Friday.

The pair was travelling in a car between Taba, near the Israeli border, and Dahab, a sea resort further south when Bedouin gunmen in a pickup truck captured them, Egyptian security sources said.

Egyptian security agencies were contacting the kidnappers to try to secure the pair's release, the sources said.

Security in the Sinai desert region has deteriorated since the overthrow of President Hosni Mubarak two years ago.

It did not appear that the Israeli had been targeted because of his nationality, two Israeli officials in Jerusalem said.

"Our initial assessment is that this was criminally motivated," one said.

Bedouin kidnappers have captured tourists in the past to push for the release of fellow tribesmen from jail. Earlier this month kidnappers briefly seized the country boss of U.S. oil major ExxonMobil and his wife.

Bedouin have attacked police stations, blocked access to towns and taken hostages to show their discontent with what they see as their poor treatment by Cairo.

Two American female tourists were kidnapped in Sinai in February last year but Egyptian authorities negotiated their release a few hours later. Two other U.S. tourists were seized in late May that year, and two more U.S. tourists in July. The captives were released within days in both cases.

Source: http://news.yahoo.com/gunmen-seize-israeli-european-tourists-egypts-sinai-123454612.html

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When Flying in a Group, Distribute Everyone's Clothing Throughout Each Suitcase So Nobody Loses Everything

When Flying in a Group, Distribute Everyone's Clothing Throughout Each Suitcase So Nobody Loses EverythingWhen one traveler's suitcase gets lost, they lose everything because all their stuff is stored in a single bag. If a group travels and distributes each person's belongings throughout every suitcase, one lost suitcase won't leave anyone with absolutely nothing. Redditor whedonmoffatparadigm explains:

At the very least, make sure each case contains at least one complete outfit for each person. That way, if one of the cases is lost, no one will be completely without a change of clothes. If you're travelling alone and are checking a bag, take a change of clothes in your carry on, for the same reason. At the very least, take a change of underwear in your carry on.

Basically, pack your bags kind of like a RAID 5 or 6 array and you can still recover easily from a loss. This might make packing and unpacking kind of a pain, but it shouldn't be too much of a problem for families.

When flying with your family, spread everyone's clothes out among several suitcases | Reddit

Photo by Kristen Taylor.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ttQLS3i9rDY/when-flying-in-a-group-distribute-everyones-clothing-throughout-each-suitcase-so-nobody-loses-everything

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Saturday, March 23, 2013

Arthritis ? a Disease or a Disorder? | Natural Holistic Health Blog

Many of us are affected by arthritis, or know someone who is. Arthritis is a condition of moderate to severe pain that affects the joints, but what exactly is it that causes some people to get arthritis while others don?t?

The quick and easy answer as to what causes arthritis is that we really don?t know yet. There?s no one answer that explains every case. There?s no arthritis disease that you catch like a cold that causes you to develop symptoms. Arthritis is simply a joint disorder that develops with time. In fact, there are over a hundred types of arthritis and many of them are probably caused by different factors.

What we do know is that there are some risk factors that increase your chances or having a problem. While they may not be the root cause of your arthritis, they could definitely be helping to further the problem along.

One of the biggest risk factors associated with arthritis is age. You know that as you get older, there?s more wear and tear on your body. Arthritis may not be caused specifically by wear and tear on the joints, but it will definitely speed up the process or increase symptoms. That is why a large number of people over 65 have arthritis, regardless of the other factors.

Another factor that can increase your chances of developing arthritis is weight. If you are overweight, you?re going to increase the stress on your joints and will likely have more problems with arthritis. Starting a diet and exercise plan now may reduce symptoms or slow the progress of the disease.

Joint injury is often a factor in developing arthritis. Just like all the other factors, it?s not a root cause; however, you?re more likely to develop arthritis in a joint that has had a previous injury. If you do injure yourself, be sure to care for it properly so it heals quickly and doesn?t get damaged again.

Doctors aren?t really sure how big a part genetics plays into the development of arthritis, but they do know it?s related. If your parents have arthritis, it?s more likely that you will as well. Although this doesn?t mean that just because your parents had it, you will too. By reducing the likeliness from other causes, you can reduce your risk.

Many people associate arthritis with athletes and other physically active people. While it would make sense that physical work would put more stress on joints and increase the likelihood of arthritis, studies really haven?t shown this to be true. While the risk of athletes developing arthritis is higher, this is associated with their increased chance of joint injury. This means you can continue your daily exercise routine (it will probably even help), but always take precautions to avoid injury.

When most people think of arthritis, they?re often thinking of osteoarthritis. However, rheumatoid arthritis is a less common but very serious illness. While symptoms can be similar the causes are not. Rheumatoid arthritis is an autoimmune disease, which means the body is actually attacking itself and causing damage to its own joints.

While you can?t prevent arthritis or control all these factors, you can take steps to reduce them, keeping yourself pain free for longer.

We Recommend:

Arthritis is not a natural part of aging?. Over 100 forms are preventable and potentially curable. Providing the body with the correct nutrients to help this process is a significant step in the right direction in achieving this objective. Arthrit-Eze is probably the most advanced natural formula on the market today. It offers potential relief and rejuvenation for all forms of arthritis, safely, naturally and without side effects.

Our R & D team has researched each ingredient in the formula at molecular level to ensure synergy and maximum efficacy. These ingredients have been combined into a single product tablet. It is arguably the most effective natural formula of its type in the world. Unlike many prescription products for arthritis, Arthrit-Eze has no negative side effects. PLUS, customers report added benefits of better skin, and overall well-being!

Free PDF Health Ebook...

Your Health in Pregnancy

? ? Simply right click the ebook title above, and choose Save As to save to your desktop!? You can find more FREE Natural Health, Wellness and Pet Ebooks at Remedies4.com!


About Dee Braun

Dee is an Adv. Certified Aromatherapist, Reiki Master, Adv. Color/Crystal Therapist, Herbalist, Dr. of Reflexology and single mom who is dedicated to helping others any way she can. One way she chooses to help is by offering information on the benefits and uses of natural health and healing methods for the well-being of both people and pets. Dee also teaches Aromatherapy, Reflexology and Color/Crystal Therapy at the Alternative Healing Academy

Source: http://www.natural-holistic-health.com/arthritis-disease-disorder/?utm_source=rss&utm_medium=rss&utm_campaign=arthritis-disease-disorder

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The cash register rings its last sale

In this Friday, Feb. 15, 2013, photo, a sales staff member at Barney's New York uses an iPod Touch to help a customer make a purchase, in New York. Stores across the country are ditching the old-fashioned, clunky cash registers and instead having salespeople _ and shoppers themselves _ checkout on smartphones and tablet computers. (AP Photo/Bebeto Matthews)

In this Friday, Feb. 15, 2013, photo, a sales staff member at Barney's New York uses an iPod Touch to help a customer make a purchase, in New York. Stores across the country are ditching the old-fashioned, clunky cash registers and instead having salespeople _ and shoppers themselves _ checkout on smartphones and tablet computers. (AP Photo/Bebeto Matthews)

In this Friday, Feb. 15, 2013, photo, a sales staff member at Barney's New York uses an iPod Touch to help a customer make a purchase, in New York. Stores across the country are ditching the old-fashioned, clunky cash registers and instead having salespeople _ and shoppers themselves _ checkout on smartphones and tablet computers. (AP Photo/Bebeto Matthews)

In this Friday, Feb. 15, 2013, photo, a sales staff member at Barney's New York uses an iPod Touch to help a customer make a purchase, in New York. Stores across the country are ditching the old-fashioned, clunky cash registers and instead having salespeople _ and shoppers themselves _ checkout on smartphones and tablet computers. (AP Photo/Bebeto Matthews)

(AP) ? Ka-ching! The cash register may be on its final sale.

Stores across the country are ditching the old-fashioned, clunky machines and having salespeople ? and even shoppers themselves ? ring up sales on smartphones and tablet computers.

Barneys New York, a luxury retailer, this year plans to use iPads or iPod Touch devices for credit and debit card purchases in seven of its nearly two dozen regular-price stores. Urban Outfitters, a teen clothing chain, ordered its last traditional register last fall and plans to go completely mobile one day. And Wal-Mart, the world's largest retailer, is testing a "Scan & Go" app that lets customers scan their items as they shop.

"The traditional cash register is heading toward obsolescence," said Danielle Vitale, chief operating officer of Barneys New York.

That the cash register is getting the boot is no surprise. The writing has been on the wall for a long time for the iconic machine, which was created in the late 1800s. The register was essential in nearly every retail location by 1915, but it now seems outdated in a world in which smartphones and tablets increasingly are replacing everything from books to ATMs to cameras.

Stores like smartphones and tablets because they take up less floor space than registers and free up cashiers to help customers instead of being tethered to one spot. They also are cheaper: For instance, Apple Inc.'s iPads with accessories like credit card readers can cost a store $1,500, compared with $4,000 for a register. And Americans increasingly want the same speedy service in physical stores that they get from shopping online.

"Consumers want the retailer to bring the register to them," said Lori Schafer, executive adviser at SAS Institute Inc., which creates software for major retailers.

J.C. Penney, a mid-price department-store chain, said the response by customers has been great since it started rolling out iPod Touch devices late last year in its 1,100 stores. The goal is to have one in the hands of every salesperson by May. The company said that about a quarter of purchases at its stores nationwide now come from an iPod Touch. ks

On a recent Thursday afternoon at a Penney store in the Manhattan borough of New York City, Debbie Guastella, 55, marveled after a saleswoman rang up three shirts she was buying on an iPod Touch.

"I think it's great," said Guastella, who lives in Huntington, N.Y. "The faster the better."

It's been a long fall for the cash register, which innovated retail as we know it. The first register was invented following the Civil War by a little known saloon owner. Before then, most store owners were in the dark about whether or not they were making a profit, and many suffered since it was easy for sales clerks to steal from the cash drawer unnoticed. But by 1915, cash registers were ubiquitous in stores across the country, with more than 1.5 million sold by then.

More recently, stores have been looking for ways to modernize checkout. Since 2003, self-checkout areas that enable customers to scan and bag their own merchandise have become commonplace in grocery and other stores. But recently, there's been a push to go further.

As a result, companies that make traditional cash registers are racing to come up with new solutions. NCR Corp., formerly known as the National Cash Register Co., was the first to manufacturer the cash register on a large scale.

Last year, the company that also makes ATMS, self-service checkout machines and airport check-in kiosks, launched a program that merges its software with the iPad. This allows store clerks to detach the iPad from the keyboard at the counter and use it as a mobile checkout device

"Retailers have more flexibility and more opportunities to change the shopping experience," said Mark Self, NCR's vice president of retail solutions marketing.

Stores themselves also are taking their cues from the success of Apple. The nation's most profitable retailer moved to mobile checkout in all of its stores in 2007. In 2011, Apple began allowing shoppers to check out their purchases using their iPhones.

Take upscale handbag maker Coach, which is using iPod Touch devices at half of its 189 factory outlet stores. The company also is testing them in a handful of its 350 regular stores.

The move has enabled Coach to start slimming down its registers to the size of small podiums, freeing up space on walls to build shelves to showcase more product, said Francine Della Badia, Coach's executive vice president of merchandising.

Della Badia, who says the additional space will be used for new shoe salons and other purposes, said most importantly, the mobile devices allow store staff to build "a more intimate connection with the customer."

Some retailers have decided to go completely mobile. Urban Outfitters, which operates more than 400 stores under its namesake brand, Anthropologie and Free People, announced in late September that all sales eventually will be rung up on iPods and iPads on swivels located at counters. The company didn't give a timeframe for when it would go completely mobile.

Urban Outfitters had given iPod Touch devices to its sales staff two years ago and the move has been very well received by shoppers, said Calvin Hollinger, the company's chief information officer in his address to investors.

Nordstrom, an upscale department-store chain that's considered within the retail industry to be the gold standard in customer service, also plans to get rid of registers altogether.

The company handed out iPod Touch devices to its staff at its 117 department stores nationwide in 2011. And by late last year, it did the same for its 110 Nordstrom Rack stores that sell lower-priced merchandise. Nordstrom, which already has removed some of the registers at its Rack stores, said it aims to phase out registers by next year.

Colin Johnson, a Nordstrom spokeswoman, said it's too early to draw any conclusions on how mobile checkout has influenced buying, but the company is learning about which technologies work best.

"We see the future as essentially mobile," Johnson said. "We don't see departments in our store as being defined by a big clunky cash register."

Not every retailer is quick to ditch registers, though. After all, there are still logistics to figure out. For instance, most retailers don't accept cash payments on mobile devices. But if they start to do so, where will they put the cash that would normally go into a register?

Additionally, sales staff walking around stores armed with mobile devices could turn off shoppers who would prefer to be left alone in aisles. Richard Robins, a 67-year-old semi-retired investment fund manager from Redonda Beach, Calif., says he would like the convenience of mobile checkout but wouldn't want to be pressured from a sales clerk while he's in the aisle.

"I don't want to be hustled," he said.

To guard against making customers uncomfortable, some retailers including Penney are training their salespeople on when to approach shoppers ? and when not to. For its part, Wal-Mart is putting checkout in the hands of the shoppers themselves.

The retailer is testing its "Scan & Go" app, which can be used on Apple devices such as iPads, in more than 200 of its more than 4,000 stores nationwide.

The app, which is aimed at reducing long checkout lines, requires that shoppers pay at self-checkout areas. So as it tests the app, Wal-Mart also is expanding the number of self-checkout areas in its stores.

"Our goal is to give choices to all of our customers however they want to shop," said Gibu Thomas, senior vice president of mobile and digital initiatives at Wal-Mart's global e-commerce division."

___

Anne D'Innocenzio can be reached at ?http://twitter.com/ADInnocenzio

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-03-22-Death%20of%20Cash%20Register/id-8b591cce00a1487cad7b0dde856ef815

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Obama warns of extremist threat in Syria

AMMAN, Jordan (AP) ? Anxious to keep Syria's civil war from spiraling into even worse problems, President Barack Obama said Friday he worries about the country becoming a haven for extremists when ? not if ? President Bashar Assad is ousted from power.

Obama, standing side by side with Jordan's King Abdullah II, said the international community must work together to ensure there is a credible opposition ready to step into the breach.

"Something has been broken in Syria, and it's not going to be put back together perfectly immediately ? even after Assad leaves," Obama said. "But we can begin the process of moving it in a better direction, and having a cohesive opposition is critical to that."

He said Assad is sure to go but there is great uncertainty about what will happen after that.

"I am very concerned about Syria becoming an enclave for extremism," Obama said, adding that extremism thrives in chaos and failed states. He said the rest of the world has a huge stake in ensuring that a functioning Syria emerges.

"The outcome is Syria is not going to be ideal," he acknowledged, adding that strengthening a credible opposition was crucial to minimizing the difficulties.

Eager to resolve another source of tension in the region, the president earlier Friday helped broker a phone call between the Israeli and Turkish prime ministers that led to the restoration of normal diplomatic relations between the two countries.

Obama had come to Jordan from Israel, where Israeli Prime Minister Benjamin Netanyahu placed a call to Turkey's Recep Tayyip Erdogan to apologize for the deaths of nine Turkish activists in a 2010 Israeli naval raid on a Gaza-bound international flotilla.

"The timing was good for that conversation to take place," Obama said.

Obama, at a joint news conference with Abdullah, said his administration is working with Congress to provide Jordan with an additional $200 million in aid this year to cope with the massive influx of refugees streaming into the country from Syria.

Abdullah said the refugee population in his country has topped 460,000 and is likely to double by the end of the year ? the equivalent of 30 million refugees in the United States, he said.

Obama also said he would "keep on plugging away" in hopes of getting the Israelis and Palestinians to reach a peace agreement.

"The window of opportunity still exists, but it's getting more and more difficult," the president said. "The mistrust is building instead of ebbing."

On Iran, Obama reiterated that the U.S. is open to "every option that's available" to keep the country from developing a nuclear weapon.

He said it would be "extraordinarily dangerous" for the world if Iran does become nuclear capable, and he expressed his desire for using diplomatic means to halt Iran's nuclear aspirations. Iran insists its nuclear program is for peaceful purposes.

"My hope and expectation is that among a menu of options, the option that involves negotiations, discussions, compromise and resolution of the problem is the one that's exercised," Obama said. "But as president of the United States I would never take any option off the table."

Obama arrived in Jordan on Friday evening, the final stop on a four-day visit to the Middle East that included his first stop in Israel as president.

He began his visit to Amman with an apology.

"I apologize for the delay," Obama told Abdullah after arriving about an hour behind schedule. "We ended up having a dust storm."

The two leaders headed to dinner after their news conference. On Saturday, Obama planned several hours of sightseeing, including a tour of the fabled ancient city of Petra, before the return trip to Washington.

Before leaving Israel, Obama paid his respects to the nation's heroes and to victims of the Holocaust. He also solemnly reaffirmed the Jewish state's right to exist.

Accompanied by Netanyahu and President Shimon Peres, Obama laid wreaths at the graves of Theodor Herzl, the founder of modern Zionism who died in 1904 before realizing his dream of a Jewish homeland, and former Israeli Prime Minister Yitzhak Rabin, who was assassinated in 1995.

He also toured the Yad Vashem Holocaust memorial, declaring afterward that it illustrates the depravity to which man can sink but also serves as a reminder of the "righteous among the nations who refused to be bystanders."

Friday's stop at Herzl's grave, together with Thursday's visit to see the Dead Sea Scrolls, the ancient Hebrew texts, were symbolic stops for Obama that acknowledged a rationale for Israel's existence that rests with its historical ties to the region and with a vision that predated the Holocaust. Obama has been criticized in Israel for his 2009 Cairo speech in which he gave only the example of the Holocaust as a reason for justifying Israel's existence.

"Here on your ancient land, let it be said for all the world to hear," Obama said. "The state of Israel does not exist because of the Holocaust, but with the survival of a strong Jewish state of Israel, such a holocaust will never happen again."

Obama and Netanyahu met for two hours over lunch. An Israeli official said that they discussed Israel's security challenges and that, in addressing the peace process with Palestinians, Netanyahu stressed the importance of security. The officials spoke on the condition of anonymity under diplomatic protocol.

Obama also squeezed in a stop in Bethlehem in the West Bank to visit the Church of the Nativity.

He had been scheduled to take a helicopter to Bethlehem but had to change plans due to unusually high winds. The route gave Obama a clear look at Israel's separation barrier with the West Bank, which runs south of Jerusalem and is the subject of weekly protests by Palestinians.

About 300 Palestinians and international pilgrims gathered near the Nativity Church, awaiting Obama's arrival. But a knot of protesters along the route held up signs stating: "Gringo, return to your colony" and "US supports Israeli injustice."

At a nearby mosque, Mohammed Ayesh, a Muslim religious official in Bethlehem, issued a plea to Obama in a speech to worshippers: "America, where are your values? Where are the human rights? Isn't it time that you interfere to make it stop?"

Amid high security, Obama toured the church with Palestinian Authority President Mahmoud Abbas. They stopped at the Grotto of the Nativity, which is said to stand where Jesus Christ was born. About 20 children waving U.S. and Palestinian flags greeted Obama in a courtyard outside the sanctuary. He posed for photographs with Abbas and Bethlehem's mayor, Vera Baboun.

At Yad Vashem, Obama donned a skull cap and was accompanied by Rabbi Israel Meir Lau, a survivor of the Buchenwald Concentration camp who lost both parents in the Holocaust. Among his stops was Yad Vashem's Hall of Names, a circular chamber that contains original testimony documenting every Holocaust victim ever identified.

"Nothing could be more powerful," Obama said.

___

Associated Press writers Dalia Nammari in Bethlehem, West Bank, and Daniel Estrin in Jerusalem contributed to this report.

Source: http://news.yahoo.com/obama-warns-extremist-threat-syria-180949203--politics.html

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Rush to the altar: Public figures proclaim support for gay marriage before Supreme Court arguments

The American Academy of Pediatrics says that a child's health benefits from a stable relationship between parents, no matter their sexual orientation.?A new poll finds 49 percent of Americans favor same-sex marriage.

By Erin McClam, Staff Writer, NBC News

Politicians, business leaders, athletes and other high-profile figures are racing to announce their support for gay marriage before the Supreme Court holds landmark arguments next week ? an unusually broad and public push.

Many of them have filed formal briefs with the court. Others have stayed out of the legal case but made public declarations that they said were carefully timed in hopes that they might sway the justices.

?Those kinds of things make the court feel that what they?re doing is sensible,? said Alan Morrison, who teaches constitutional law at George Washington University. ?It may not affect the constitutional questions, but the court does want to feel comfortable.?

On Thursday, the American Academy of Pediatrics, which represents 60,000 doctors, published a policy statement saying that whether a child is raised by gay or straight parents has no effect on development.

Dr. Thomas McInerny, president of the academy, told NBC News that the policy change was in the works for two years but that the academy hurried its announcement so the policy would be available for the justices.

?We are an apolitical organization,? he said. ?On the other hand, we do feel very strongly about the best interests of children.?

The court will hear arguments in two cases. One is about Proposition 8, a ban on gay marriage approved by California voters in 2008. The other is about the 1996 Defense of Marriage Act, which blocked federal recognition of same-sex unions.

In the final days before a Supreme Court deadline to file papers in both cases, prominent Republicans rushed to add their names to a brief arguing that gay marriage promotes the conservative values of stability and mutual obligation.

Besides former governors and members of Congress, the 131 signers of the brief included top aides in the administration of George W. Bush and senior advisers to the presidential campaigns of Sen. John McCain in 2008 and Mitt Romney last year.

And last week, Sen. Rob Portman of Ohio became the first Republican senator to support same-sex marriage. Portman, whom Romney considered as a running mate, said that he had had a change of heart on the matter after his son, who is 21, came out.

Portman did not sign the Republican brief before the Supreme Court but said that the upcoming arguments were a factor in his decision to go public.

Hillary Rodham Clinton, the former secretary of state and a potential Democratic presidential candidate in 2016, released a video last week through a gay rights group and said flatly: ?I support marriage for lesbian and gay couples.? As a candidate in 2008, she had opposed gay marriage but supported civil unions.

Her announcement came after her husband, who signed the Defense of Marriage Act into law as president, published an Op-Ed in The Washington Post encouraging the Supreme Court to overturn it.

?I now know that, even worse than providing an excuse for discrimination, the law itself is discriminatory,? he wrote.

Morrison, from George Washington University, who filed a brief that called parts of DOMA ?utterly irrational,? said that the gay rights cases may be unprecedented in drawing support from such a broad spectrum of society.

Earlier this month, more than 100 corporations, including Google, Nike and Estee Lauder, signed two briefs in support of gay marriage ? arguing that blocking recognition is just not legally wrong but hurts their businesses.

Lloyd Blankfein, the head of the investment bank Goldman Sachs, told The New York Times that captains of industry ?wanted to attach themselves to what may be the last great civil rights issue of our time.?

And on Monday, Rashad Evans, a mixed martial arts fighter, told the gay website Outsports that he felt a duty to support gay rights as a competitor in ?a macho-type sport.?

?I have kids,? he told the site. ?I don?t want them growing up in a society where they, or their friends, could be second-class citizens based on which person they fall in love with or who they want to be happy with.?

He joined a brief filed by Chris Kluwe, a punter for the Minnesota Vikings, and Brendon Ayanbadejo, a linebacker for the Baltimore Ravens.

Marc Solomon, national campaign director for the gay rights group Freedom to Marry, said that his group was pleased that the cause had drawn such broad support, particularly from the political right.

?Our side has put forth the most powerful case that could be made that America is ready,? he said. ?There is no question that justices live in the real world.?

Polls show increasing public support for gay marriage. A Washington Post-ABC survey earlier this week found 58 percent for gay marriage and 36 percent opposed ? a mirror image of public opinion less than a decade ago.

Brian Brown, president of the National Organization for Marriage, a leading group opposed to same-sex marriage, said that the pediatrics academy had taken a ?transparently political step? by endorsing gay marriage and had been influenced by studies produced by gay-marriage advocates.

?Which parent can a child do without ? her mother or her father?? he said in a statement. ?We remain confident that the U.S. Supreme Court will uphold the ability of states and the federal government to define marriage as the union of a man and a woman, a definition that has served our nation well for hundreds of years.?

Another group opposed to gay marriage, the Traditional Values Coalition, mocked Portman?s announcement last week by publishing a hypothetical statement from a parent who came out in favor of drunken driving because her son is a drunk driver.

When the Supreme Court takes up the question Tuesday and Wednesday, most of the public statements won?t matter, said Tom Goldstein, a founder of the widely read Scotusblog, which analyzes the court.

What?s more, he said, ?Some of these developments are a double-edged sword. The cases rely to some extent on the notion that homosexuals face widespread discrimination and hostility. The fact that the country is coming around so fast ironically could hurt their cause in court.?

The announcement by the pediatrics academy could matter because it speaks directly to conservatives and their concerns in the case, he said, but ?what someone thinks in Hollywood couldn?t be more irrelevant.?

This story was originally published on

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Baby Sleeping Sacks Take Away Parents' Insecurity About SIDS

Sudden Infant Death Syndrome (SIDS) is the major unpleasant misfortune which parents have to face with infants and children up to three years of age. This issue arises most number of times because of the fluctuating body temperatures of their infant, inadequate ventilation and high or sudden heat entrapment in the sleeping arrangement. To curb this issue, the Association of American Paediatrics have given various guidelines which must be strictly adhered to. One of the good things about those guidelines is that the sleeping bags materials are approved by their standards and only the bags made of approved material must be purchased.

Simplistic and home made sleeping sacks for babies are also not very advisable because the toxicity of the material in a home made sack can't be ensured. Also, the design of baby sleeping sacks made in factories ensure that the sleeping baby doesn't slip into the bag. For this proper neck and shoulder fitting are provided in the sack. Even the zipped sleep sacks have the consideration of eliminating the harder and hazardous zippers. The soft zippers which can be operated from two sides give a good capability of performance.

For babies who start kicking and staggering during the sleep, the arrangement must be quite loose and spacious, so that they don't feel irritated with the jammed quilts. Also, if sheets, quilts or blankets are used for them, they are likely to kick them off very easily and then face the trouble of anything thereafter. The baby sleeping bags eliminate this problem. They are zip-closed that's why never go off the body. Also, they are sufficiently loose to allow a baby's sleep-dance/violence.

They have no sleeves to ensure that the baby's arms remain free for movement in the sleep.

Thereafter, it gets secure for parents, mentally, that their kid is not in a risk of its life. Reported problems keep getting eliminated by companies and renovated products keep coming in the market really fast. One of the researched and developed product is the quilted baby sleeping bag for winter season. The baby remains warm and protected in this well insulated and easily breathable material bag. It comes in pleasant colours and has certified non toxic substance which can be easily cleaned and dried. It gets the better of those blankets and quilts which you regularly need to adjust at nights and ensure are keeping your baby warm all the time. The quilts are also susceptible to cover your baby's face due to baby's movement. This threatens a suffocated sleep for the infant which no one can afford.

Sleeping bags baby is more protected and easy-sleeping than a quilt or blanket covered infant who is always under a threat of suffocation.

Source: http://sleeping.ezinemark.com/baby-sleeping-sacks-take-away-parents-insecurity-about-sids-7d3872145e71.html

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Friday, March 22, 2013

Enzymes allow DNA to swap information with exotic molecules

Mar. 21, 2013 ? The discovery of the Rosetta Stone resolved a longstanding puzzle, permitting the translation of Egyptian hieroglyphs into Ancient Greek.

John Chaput, a researcher at Arizona State University's Biodesign Institute has been hunting for a biological Rosetta Stone -- an enzyme allowing DNA's 4-letter language to be written into a simpler (and potentially more ancient) molecule that may have existed as a genetic pathway to DNA and RNA in the prebiotic world.

Research results, which recently appeared in the Journal of the American Chemical Society, demonstrate that DNA sequences can be transcribed into a molecule known as TNA and reverse transcribed back into DNA, with the aid of commercially available enzymes.

The significance of the research is three-fold:

  • It offers tantalizing clues about how DNA and RNA -- which encode the building plans for all earthly life -- may have arisen from more primitive information-carrying molecules
  • Contributes to the field of exobiology -- the search for alternative life forms elsewhere in the universe
  • Points to possible applications for TNA and other unusual nucleic acid molecules (known as xenonucleic acids or XNAs) in molecular medicine.

In the case of biomedical applications, XNAs may be developed into aptamers -- molecular structures that can mimic the properties of naturally occurring polymers, folding into a variety of 3-dimensional forms and binding with selected targets. Aptamers are useful for a range of clinical applications including the development of macromolecular drugs.

"TNA is resistant to nuclease degradation, making it an ideal molecule for many therapeutic and diagnostic applications," Chaput says.

The structural plans for organisms ranging from bacteria to primates (including humans) are encrypted in DNA using an alphabetic code consisting of just A, C, T & G, which represent the 4 nucleic acids. In addition to their information-carrying role, DNA and RNA possess two defining properties: heredity, (which allows them to propagate their genetic sequences to subsequent generations) and evolution, (which allows successive sequences to be modified over time and to respond to selective pressure).

The chemical complexity of DNA has convinced most biologists that it almost certainly did not arise spontaneously from the prebiotic soup existing early in earth's history. According to one hypothesis, the simpler RNA molecule may at one time have held dominion as the sole transmitter of the genetic code. RNA is also capable of acting as an enzyme and may have catalyzed important chemical reactions leading eventually to the first cellular life.

But RNA is still a complex molecule and the search for a simpler precursor that may have acted as a stepping-stone to the RNA, DNA and protein system that exists today has been intense.

A variety of xenonucleic acids are being explored as candidates for the role of transitional molecule. In the current study, threose nucleic acid or TNA is investigated. Chaput says that establishing TNA as a progenitor of RNA would require demonstrating that TNA can perform functions that would help support a pre-RNA world. Of particular importance, would have been the ability replicate itself in the absence of protein enzymes.

Like DNA, TNA can form double-helices -- spiral staircase structures consisting of the 4 nucleotide bases, which make up the ladder-like rungs, and a sugar and phosphorus backbone, which forms the ladder's railing. The sugar portion of this backbone is a defining component of the nucleic acid. DNA uses deoxyribose, RNA uses ribose and TNA uses threose.

Both DNA and RNA have sugars containing five carbon atoms, but TNA's threose sugar contains only four. This enables TNA to assemble from just two identical carbon units, making it far easier to form under the non-biological conditions than RNA or DNA.

Despite TNA's chemical distinctiveness, it is similar enough to DNA and RNA to be able to interact with these familiar molecules and exchange information. In addition to forming helices, TNA segments can bind with complementary DNA and RNA strands through Watson-Crick base pairing, thus making TNA an alternate self-replicating entity. The study of TNA and other artificially-produced genetic polymers is part of a rapidly emerging discipline known as synthetic genetics.

Powerful tools allow for high-throughput production of molecules with specified traits, built from xenonucleic acid molecules like TNA. In the current study, Chaput and his research team demonstrate that certain commercially available enzymes can facilitate the transcription of DNA sequences into TNA and back again into DNA and that the TNA sequences can be induced to evolve under the influence of environmental cues. The process is known as in vitro selection.

To accomplish this, large pools of TNA molecules are produced from DNA templates and then exposed to a particular molecular target. The small fraction of the random-sequence TNA strands structurally capable of binding with the target are extracted and reverse-transcribed back into DNA, then amplified using polymerase chain reaction (PCR).

The process can be repeated, allowing for significant enrichment of the desired aptamer. Indeed, the authors note that a single round of selection in their experiment produced a 380-fold enrichment from an original library of 1014 DNA templates. The authors note that the method is therefore capable of pinpointing and enriching a particular aptamer of predefined function from a staggering 1015 non-functional sequences. (One potential benefit of constructing aptamers from TNA is improved stability -- natural enzymes that rapidly break down DNA and RNA do not degrade them.)

Prior to the current study, researchers had been frustrated that only severely abbreviated lengths of DNA could be faithfully transcribed into TNA. The limiting factor in the process was an effective enzyme to guide the accurate transcription of the DNA message. In the case of normal biological transcription, DNA is transcribed into RNA with the help of a specific enzyme known as DNA polymerase. Such naturally occurring polymerases, Chaput points out, are highly specific, and don't work well for DNA to TNA transcription or reverse transcription.

Recent advances in protein engineering however, have produced a new breed of synthetic polymerases. In the current study, one of these -- known as Therminator DNA polymerase, faithfully transcribed a 70 nucleotide DNA sequence into TNA, while another, known as SuperScript II (SSII) performed reverse-transcription back into DNA with impressively high fidelity. Sequences of both 3-letter and 4-letter DNA messages were transcribed and reverse transcribed, both with over 90 percent accuracy.

The research paves the way for more sophisticated manipulation of TNA and other xenonucleic acids and may strengthen the case that TNA or a closely related molecule set the stage for the emergence of RNA and the first earthly life.

Given the enormous potential for this research for the fields of synthetic biology, exobiology and medicine, it is likely that XNAs will be produced in greater abundance by large chemical laboratories. Currently, the synthesis and purification of nucleoside triphosphates needed to form XNA backbones remains a delicate and labor-intensive process.

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Story Source:

The above story is reprinted from materials provided by Arizona State University. The original article was written by Richard Harth, Science Writer, Biodesign Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Hanyang Yu, Su Zhang, Matthew R. Dunn, John C. Chaput. An Efficient and Faithful in Vitro Replication System for Threose Nucleic Acid. Journal of the American Chemical Society, 2013; 135 (9): 3583 DOI: 10.1021/ja3118703

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/kDp0kX-ErQM/130321151933.htm

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Energy drinks will be prohibited to be sold to minors | Baltic News ...

Thursday, March 21, the parliament will be reviewing the Energy Drink Circulation Law and will be deciding on restrictions on sales of this product. It is planned to prohibit the selling of energy drinks to minors starting from 2014. It is also planned to limit the sale of this product in schools and other education institutions. Shops will be required to put energy drinks on separate shelves.

Restrictions will also apply to advertisements ? young people are not to be the target audience. Endocrinologist Iveta Dzivite-Krisane told LTV and Latvian Radio?s internet news portal that children are likely to become addicted to this sugary and caffeine rich type of drink.

?In my opinion as a doctor, I believe these drinks need to be limited and made unavailable for children. There have not been any children with acute changes in children, but theoretically speaking contents of energy drinks can cause changes in the metabolism of glucose and amino acids. Systematic consumption of these drinks could lead to serious health problems for children. Energy drinks should be prohibited for children. This is not about production. Energy drinks cause addiction if consumed on a regular basis, something sweets are unable to do,? ? the doctor says.

The sale of energy drinks is currently prohibited in Latvian schools. In the bill, energy drinks are defined as ?non-alcoholic drinks that contain stimulating substances or tonics, including caffeine, the total proportion of which among other ingredients exceeds 150 mg/l of carbohydrates, amino acids, minerals and vitamins, including B-group vitamins and other additives.?

Authors of the bill note that there is no single definition to ?energy drink? in the EU. Energy drinks are generally considered non-alcoholic drinks that contain sugar, caffeine and other additives like taurine, riboflavin, pyridoxine, and nicotinamide, vitamin B and different plant derivatives.

No country of the EU has full prohibition of energy drinks, but Germany, Bulgaria, Denmark, Lithuania, Estonia, Hungary, Iceland, Slovakia, Austria, Finland and Sweden have specific trade restrictions.

Ref: 102.109.109.6725

Source: http://bnn-news.com/sales-energy-drinks-minors-prohibited-91288

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Pre-caffeine tech: Twitter birthdays, Android attitude

Our pre-caffeine roundup is a collection of the hottest, strangest, and most amusing stories of the morning.

Drones crash ... a lot. But at least we're learning something from their troubles.

Salvagers backed by Amazon.com founder Jeff Bezos recovered components from Apollo rocket engines from the bottom of the Atlantic Ocean. Next-day shipping was probably a bit pricey.

Scientists say they're intrigued by two new species of woodlizards found in the Peruvian jungle, and not just because of their scary-cool looks.

Some new glasses-free 3-D tech could feel like having a hologram in your pocket.

Smartphone hacking is coming of age, some suggest. Yes, this is as scary as you might imagine.

Twitter's celebrating its seventh birthday. No word on whether anyone gave Larry the Twitter Bird a slice of cake.

How many Tetris pieces would you need to build a full-size house? About 1.12 billion, some folks claim.

Facebook may be testing out a new feature which will nag you to update your Facebook status.

YouTube revealed that it has a billion active users. This, the video-sharing site claims, means that nearly one out of every two people on the Internet visits YouTube.

Google's starting to remove links to Google Reader. The Internet continues crying for the retiring tool.

In closing: Has anyone seen my favorite Android pin anywhere? The little guy had an attitude, but I miss him.

Want more tech news or interesting links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on Twitter, subscribing to her Facebook posts, or circling her on Google+.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/29d3c488/l/0L0Snbcnews0N0Ctechnology0Ctechnolog0Cpre0Ecaffeine0Etech0Etwitter0Ebirthdays0Eandroid0Eattitude0E1C8985283/story01.htm

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Average for US jobless claims at fresh 5-year low

(AP) ? The number of people seeking U.S. unemployment aid barely changed last week, while the average over the past month fell to a fresh five-year low. The decline in layoffs is helping strengthen the job market.

Weekly unemployment benefit applications rose just 2,000 to a seasonally adjusted 336,000, the Labor Department said Thursday.

Over the past four weeks, applications have dropped by 7,500 to 339,750. That's the lowest since February 2008, just three months into the recession.

Economists pay close attention to the four-week average because it can smooth out week to week fluctuations. The steady decline in unemployment claims signals that companies are laying off fewer workers. That suggests many aren't worried about economic conditions in the near future.

"Improvement in labor market conditions continues," Julia Coronado, an economist at BNP Paribas, said in a note to clients.

The four-week average has fallen nearly 15 percent since November. The trend has coincided with acceleration in the job market.

Employers have added an average of 200,000 jobs per month since November. That's nearly double the average from last spring.

And in February, the unemployment rate fell to a four-year low of 7.7 percent.

Jennifer Lee, an economist at BMO Capital Markets, said the drop in the average number of unemployment applications over the past month suggests job gains in March could top 200,000.

Nearly 5.4 million people were receiving unemployment aid as of the week ended March 2, the latest data available. That was about 250,000 fewer than the previous week. The data on total unemployment benefit recipients are not seasonally adjusted and is volatile.

The job market is benefiting from stronger auto sales and a healthy recovery in housing. Homebuilding permits jumped to their highest level in 4 ? years in February, suggesting that recent strong gains in home construction will continue. New-home sales jumped 16 percent in January to the highest level since July 2008. Auto sales, meanwhile, rose in January and February after hitting a five-year high in 2012.

The housing and auto sectors are being helped by the Federal Reserve's efforts to keep interest rates low, policies the Fed stood by Wednesday after a two-day meeting.

The Fed reinforced its plan to keep short-term interest rates at record lows at least until unemployment falls to 6.5 percent, as long as the inflation outlook remains mild. And it said it would continue buying $85 billion a month in bonds indefinitely to keep long-term borrowing costs down.

During a news conference after the meeting, Chairman Ben Bernanke acknowledged the job market has accelerated but said the Fed wants to see sustained improvement before altering its stimulus policies. Unemployment benefit applications are one of the measures Bernanke said the Fed is closely monitoring.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-21-US-Unemployment-Benefits/id-fb92dfc622e44006a379f1ef33183c74

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